PMID- 7570670
OWN - NLM
STAT- MEDLINE
DCOM- 19951106
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 79
IP  - 1-3
DP  - 1995 Sep
TI  - Extrapolating the future: research trends in modeling.
PG  - 299-303
AB  - The proceedings in this volume suggest several important future research needs. 
      Research is needed to validate modeling in toxicology in order to support the use 
      of the general approach of modeling, either for structure-activity relationships 
      (SAR) or physiologically based pharmacokinetics (PBPK), by regulators. Research 
      is needed to demonstrate how SAR predictions can be integrated with the PBPK 
      models to reduce the chemical-specific, intensive data requirements of PBPK 
      models. Methods are needed to harmonize modeling approaches and to educate 
      potential users. New approaches to modeling are needed which go beyond present 
      day assumptions of flow-limited models into dynamic models of human health 
      effects. The academic community can further these objectives by including applied 
      mathematics of toxicology, including both SAR and PBPK modeling, in toxicology 
      curricula.
FAU - Menzel, D B
AU  - Menzel DB
AD  - Department of Community and Environmental Medicine, University of California, 
      Irvine 92717, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Hazardous Substances)
SB  - IM
MH  - Animals
MH  - *Hazardous Substances/pharmacokinetics/toxicity
MH  - Humans
MH  - *Models, Biological
MH  - *Research
MH  - Risk Assessment
MH  - Structure-Activity Relationship
MH  - Toxicology/*trends
RF  - 8
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 0378-4274(95)03382-U [pii]
AID - 10.1016/0378-4274(95)03382-u [doi]
PST - ppublish
SO  - Toxicol Lett. 1995 Sep;79(1-3):299-303. doi: 10.1016/0378-4274(95)03382-u.