PMID- 7571228
OWN - NLM
STAT- MEDLINE
DCOM- 19951109
LR  - 20131121
IS  - 0090-4295 (Print)
IS  - 0090-4295 (Linking)
VI  - 46
IP  - 4
DP  - 1995 Oct
TI  - Flutamide-induced cryptorchidism in the rat is associated with altered 
      gubernacular morphology.
PG  - 553-8
AB  - OBJECTIVES: One of the major controversies regarding descent of the testes is 
      whether androgenic regulation of the gubernaculum testes exists. To determine if 
      antiandrogens can alter the development of the gubernaculum within the fetus, the 
      following experiment was performed. METHODS: Timed pregnant Sprague-Dawley rats 
      were treated with either flutamide, dihydrotestosterone (DHT), or vehicle alone 
      (controls) from gestational day (GD) 15 to 17. Fetal specimens were removed via 
      cesarean section on GD 18 and 20. Serial coronal sections were obtained, and 
      digital microscopy with computer-assisted reconstruction was used to ascertain 
      the morphology of the three components of the gubernaculum, that is, the 
      gubernacular cord and the mesenchymal and muscular components of the gubernacular 
      bulb. RESULTS: Flutamide significantly prevented and DHT significantly enhanced 
      gubernacular cord regression compared with controls (P < 0.01). Flutamide also 
      resulted in a significant inhibition of the gubernacular bulb outgrowth, with 
      diminution of both the mesenchymal and muscular components of the gubernacular 
      bulb. CONCLUSIONS: These data suggest that androgens play an active role in 
      gubernacular cord regression and gubernacular outgrowth within the fetal rodent.
FAU - Cain, M P
AU  - Cain MP
AD  - Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA.
FAU - Kramer, S A
AU  - Kramer SA
FAU - Tindall, D J
AU  - Tindall DJ
FAU - Husmann, D A
AU  - Husmann DA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
RN  - 0 (Androgen Antagonists)
RN  - 76W6J0943E (Flutamide)
SB  - IM
MH  - Androgen Antagonists/*pharmacology
MH  - Animals
MH  - Cryptorchidism/*chemically induced
MH  - Female
MH  - Flutamide/*pharmacology
MH  - Gestational Age
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Testis/anatomy & histology/*drug effects/*embryology
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - S0090-4295(99)80272-6 [pii]
AID - 10.1016/S0090-4295(99)80272-6 [doi]
PST - ppublish
SO  - Urology. 1995 Oct;46(4):553-8. doi: 10.1016/S0090-4295(99)80272-6.