PMID- 7573417
OWN - NLM
STAT- MEDLINE
DCOM- 19951106
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 269
IP  - 3 Pt 1
DP  - 1995 Sep
TI  - Interaction of decreased arterial PO2 and exercise on carbohydrate metabolism in 
      the dog.
PG  - E409-17
AB  - To determine the mechanism by which low arterial PO2 (PaO2) affects muscle 
      carbohydrate (CHO) metabolism during exercise, dogs inhaled gas consisting of 
      0.21 (NO; n = 6) or 0.11 (LO; n = 6) inspired oxygen fraction (FIO2) during rest 
      and 150 min of moderate treadmill exercise. Limb arteriovenous difference and 
      isotopic ([3H]- and [14C]glucose) methods were used to assess muscle carbohydrate 
      metabolism: PaO2 was reduced by approximately 50% in LO vs. NO, but limb O2 
      uptake was similar. Glucose disappearance was increased during rest (13 +/- 2 vs. 
      19 +/- 1 mumol.kg-1.min-1) and exercise (23 +/- 4 vs. 36 +/- 6 mumol.kg-1.min-1 
      at 150 min) in LO vs. NO, but arterial glucose was unchanged because hepatic 
      glucose production was increased similarly. Limb glucose and pyruvate oxidation 
      (derived from vein [14C]lactate specific activity) rates were elevated about 
      twofold during rest and exercise in LO vs. NO. Estimated limb glycogenolysis 
      increased at rest (21 +/- 9 vs. 96 +/- 23 mumol/min) and during exercise (70 +/- 
      21 vs. 184 +/- 41 mumol/min at 150 min) in LO vs. NO. The %CO2 and %lactate from 
      glucose in LO were about twofold the values in NO in rest and exercise. The %CO2 
      from pyruvate was greater and free fatty acid levels were lower, suggesting 
      reduced fat metabolism in LO. Arterial lactate and pyruvate levels were elevated 
      during rest and the initial 30 min of exercise, even though net limb outputs were 
      no greater. Lactate-to-pyruvate ratios and pH were similar in LO and NO during 
      exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Zinker, B A
AU  - Zinker BA
AD  - Department of Molecular Physiology and Biophysics, Vanderbilt University School 
      of Medicine, Nashville, Tennessee 37232-0615, USA.
FAU - Wilson, R D
AU  - Wilson RD
FAU - Wasserman, D H
AU  - Wasserman DH
LA  - eng
GR  - DK-20593/DK/NIDDK NIH HHS/United States
GR  - R01 DK-42488/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Glucose)
RN  - 0 (Lactates)
RN  - 0 (Pyruvates)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 8558G7RUTR (Pyruvic Acid)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Arteries
MH  - Blood Glucose/metabolism
MH  - *Carbohydrate Metabolism
MH  - Dogs
MH  - Female
MH  - Hemodynamics
MH  - Lactates/blood
MH  - Lactic Acid
MH  - Male
MH  - Oxygen/*blood
MH  - Partial Pressure
MH  - *Physical Exertion
MH  - Pyruvates/blood
MH  - Pyruvic Acid
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1152/ajpendo.1995.269.3.E409 [doi]
PST - ppublish
SO  - Am J Physiol. 1995 Sep;269(3 Pt 1):E409-17. doi: 10.1152/ajpendo.1995.269.3.E409.