PMID- 7574775
OWN - NLM
STAT- MEDLINE
DCOM- 19951109
LR  - 20131121
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 22
IP  - 11
DP  - 1995 Sep
TI  - [Intraperitoneal infusion therapy of MTX and 5-FU for advanced gastric cancer and 
      its peritoneal metastasis].
PG  - 1619-21
AB  - We administered methotrexate (MTX) and 5-fluorouracil (5-FU) into the peritoneal 
      cavity as chemotherapy after operation for advanced gastric cancer from a port 
      implanted subcutaneously during the operation, every or every other week. It has 
      been said that MTX tends to be kept in the peritoneal cavity, so the kinetics of 
      MTX is important when it was administered there in. We investigated the 
      concentrations of MTX in the peritoneal cavity and serum with infusion into the 
      peritoneal cavity (IP), and compared it with intraarterial (IA) and intravenous 
      (IV) administration. The results were the lower serum concentration of MTX in IP 
      than in both IA and IV at 1-2 hours after infusion, but thereafter it was the 
      same level in each group. The intraperitoneal concentration of MTX was lower than 
      the detectable level at 24-48 hours after infusion. On the other hand, we 
      investigated the side effects of this therapy, and only one of 20 cases given 
      therapy many times had nausea and vomiting. So the intraperitoneal infusion 
      therapy of MTX and 5-FU seemed to be safe.
FAU - Takamatsu, S
AU  - Takamatsu S
AD  - Dept. of Surgery, Tokyo Metropolitan Ohkubo Hospital.
FAU - Maruyama, M
AU  - Maruyama M
FAU - Sugano, N
AU  - Sugano N
FAU - Katada, M
AU  - Katada M
FAU - Ebuchi, M
AU  - Ebuchi M
LA  - jpn
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - U3P01618RT (Fluorouracil)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Drug Administration Schedule
MH  - Fluorouracil/administration & dosage
MH  - Humans
MH  - *Infusion Pumps, Implantable
MH  - Infusions, Parenteral
MH  - Lymphatic Metastasis
MH  - Methotrexate/administration & dosage
MH  - Middle Aged
MH  - Peritoneal Neoplasms/*drug therapy/*secondary
MH  - Stomach Neoplasms/*drug therapy/pathology
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 1995 Sep;22(11):1619-21.