PMID- 7576951
OWN - NLM
STAT- MEDLINE
DCOM- 19951221
LR  - 20220330
IS  - 0959-8049 (Print)
IS  - 0959-8049 (Linking)
VI  - 31A
IP  - 4
DP  - 1995
TI  - Gene expression and neuroblastoma cell differentiation in response to retinoic 
      acid: differential effects of 9-cis and all-trans retinoic acid.
PG  - 486-94
AB  - Retinoic acid has considerable potential for the chemoprevention and chemotherapy 
      of cancer. Neuroblastoma cells differentiate in response to retinoic acid in 
      vitro, an observation that has led to clinical trials using either the 13-cis or 
      all-trans isomers of retinoic acid. We review the effects of retinoic acid on 
      neuroblastoma, and the potential involvement of nuclear retinoic acid receptors 
      (RARs) and retinoid X receptors (RXRs). 9-cis retinoic acid is a ligand for RXRs, 
      and we review recent data on the differential effects of 9-cis and all-trans 
      retinoic acid on neuroblastoma differentiation and proliferation in vitro, and 
      possible mechanisms of action via hetero- and homodimers of RARs and RXRs. 
      Although there is uncertainty whether or not 9-cis retinoic acid produces its 
      biological effects primarily via RXR homodimers, in vitro data suggest that this 
      isomer of retinoic acid or stable analogues may have considerable potential for 
      the treatment of resistant, disseminated neuroblastoma.
FAU - Redfern, C P
AU  - Redfern CP
AD  - Department of Medicine, Medical School, University of Newcastle, U.K.
FAU - Lovat, P E
AU  - Lovat PE
FAU - Malcolm, A J
AU  - Malcolm AJ
FAU - Pearson, A D
AU  - Pearson AD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
RN  - 0 (Antineoplastic Agents)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Cell Differentiation/*drug effects
MH  - Cell Division/drug effects
MH  - Gene Expression Regulation, Neoplastic/*drug effects
MH  - Humans
MH  - Neuroblastoma/*genetics/pathology
MH  - Phenotype
MH  - Tretinoin/*pharmacology
MH  - Tumor Cells, Cultured/drug effects
RF  - 73
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 0959-8049(95)00066-R [pii]
AID - 10.1016/0959-8049(95)00066-r [doi]
PST - ppublish
SO  - Eur J Cancer. 1995;31A(4):486-94. doi: 10.1016/0959-8049(95)00066-r.