PMID- 7577625
OWN - NLM
STAT- MEDLINE
DCOM- 19951204
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 91
IP  - 1
DP  - 1995 Sep
TI  - Large-cell anaplastic non-Hodgkin's lymphoma originating in donor cells after 
      allogenic bone marrow transplantation.
PG  - 162-6
AB  - Second neoplasms after allogenic bone marrow transplantation (BMT) occur in donor 
      cells; however, host origin generally cannot be excluded. Using fluorescence in 
      situ hybridization (FISH) the origin of the malignant population can be proven 
      indisputably. In a female patient with CD30+ large-cell anaplastic non-Hodgkin's 
      lymphoma (LCAL) after BMT with an HLA-identical brother donor, FISH using 
      anti-CD30 immunocytochemistry in combination with anti-Y- and anti-EBV RNA probes 
      was applied. In pathological lymph nodes the majority of cells were of donor type 
      (Y). CD30-positive cells were Y-positive; these cells were also EBV-positive. 
      Using FISH and immunocytochemistry we have demonstrated convincingly that this, 
      possibly EBV-induced, LCAC originated in donor cells.
FAU - Schouten, H C
AU  - Schouten HC
AD  - Department of Internal Medicine, University Hospital Maastricht/University 
      Limburg Maastricht, The Netherlands.
FAU - Hopman, A H
AU  - Hopman AH
FAU - Haesevoets, A M
AU  - Haesevoets AM
FAU - Arends, J W
AU  - Arends JW
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Female
MH  - Herpesviridae Infections/complications
MH  - Herpesvirus 4, Human/*isolation & purification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large-Cell, Anaplastic/*virology
MH  - Middle Aged
MH  - Neoplasms, Second Primary/pathology/*virology
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*therapy
MH  - Transplantation, Homologous
MH  - Tumor Virus Infections/complications
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1111/j.1365-2141.1995.tb05262.x [doi]
PST - ppublish
SO  - Br J Haematol. 1995 Sep;91(1):162-6. doi: 10.1111/j.1365-2141.1995.tb05262.x.