PMID- 7578254
OWN - NLM
STAT- MEDLINE
DCOM- 19951204
LR  - 20191210
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1264
IP  - 1
DP  - 1995 Oct 17
TI  - Analysis of cis-acting regions upstream of the rat Na+/K(+)-ATPase alpha 1 
      subunit gene by in vivo footprinting.
PG  - 35-9
AB  - By means of in vivo footprinting, we examined the putative cis-acting DNA 
      elements located between -50 and -122 of rat Na+/K(+)-ATPase alpha 1 subunit gene 
      ATP1A1. Proximal and distal GC box sequences and a consensus sequence for the 
      active transcription factor (ATF) were protected for all the tissues examined 
      (kidney, brain and liver). Putative cooperation between two binding factors on 
      the ATF site and the proximal GC box was observed. The overall in vivo 
      footprinting profiles of the three tissues did not exhibit any marked differences 
      that could account for the variation in the extent of tissue-specific 
      transcription. The alpha 1 regulatory element (ARE) found by Suzuki-Yagawa et al. 
      does not appear to be an element responsible for tissue-specific regulation of 
      the gene.
FAU - Nomoto, M
AU  - Nomoto M
AD  - Department of Molecular Biology, University of Occupational and Environmental 
      Health, Japan.
FAU - Gonzalez, F J
AU  - Gonzalez FJ
FAU - Mita, T
AU  - Mita T
FAU - Inoue, N
AU  - Inoue N
FAU - Kawamura, M
AU  - Kawamura M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 9007-49-2 (DNA)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Brain/enzymology
MH  - DNA/analysis
MH  - DNA Footprinting
MH  - Kidney/enzymology
MH  - Liver/enzymology
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Rats
MH  - Sodium-Potassium-Exchanging ATPase/chemistry/*genetics
EDAT- 1995/10/17 00:00
MHDA- 1995/10/17 00:01
CRDT- 1995/10/17 00:00
PHST- 1995/10/17 00:00 [pubmed]
PHST- 1995/10/17 00:01 [medline]
PHST- 1995/10/17 00:00 [entrez]
AID - 0167-4781(95)00158-D [pii]
AID - 10.1016/0167-4781(95)00158-d [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1995 Oct 17;1264(1):35-9. doi: 
      10.1016/0167-4781(95)00158-d.