PMID- 7579330
OWN - NLM
STAT- MEDLINE
DCOM- 19951219
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 86
IP  - 10
DP  - 1995 Nov 15
TI  - Role of light chain variable region in myeloma with light chain deposition 
      disease: evidence from an experimental model.
PG  - 3655-9
AB  - Light chain deposition disease (LCDD) results from a propensity of some human 
      monoclonal L chains to form tissue deposits. We designed an experimental model 
      for in vivo expression of human kappa L chain sequences in mice and compared a 
      somatically mutated LCDD chain with a closely related control kappa chain, both 
      encoded by the unique V kappa IV gene. Mice secreting the LCDD chain but not 
      those producing the control chain showed deposits with a distribution similar to 
      that observed in patients. These data show that discrete changes in V region 
      sequences can play a major role in tissue deposition of human L chains.
FAU - Khamlichi, A A
AU  - Khamlichi AA
AD  - Laboratoire d'Immunologie et Genetique, CNRS URA 1172, IBMIG, Faculte des 
      Sciences, Poitiers, France.
FAU - Rocca, A
AU  - Rocca A
FAU - Touchard, G
AU  - Touchard G
FAU - Aucouturier, P
AU  - Aucouturier P
FAU - Preud'homme, J L
AU  - Preud'homme JL
FAU - Cogne, M
AU  - Cogne M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Immunoglobulin Variable Region)
RN  - 0 (Immunoglobulin kappa-Chains)
RN  - 0 (Myeloma Proteins)
RN  - 0 (Recombinant Fusion Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies, Monoclonal/genetics
MH  - *Disease Models, Animal
MH  - *Genes, Immunoglobulin
MH  - Humans
MH  - Hybridomas/metabolism/transplantation
MH  - Immunoglobulin Variable Region/*genetics
MH  - Immunoglobulin kappa-Chains/*genetics
MH  - Kidney Diseases/*etiology/genetics/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Multiple Myeloma/*genetics/pathology
MH  - Myeloma Proteins/*genetics
MH  - Paraproteinemias/genetics/pathology
MH  - Recombinant Fusion Proteins/biosynthesis/toxicity
MH  - Retroperitoneal Neoplasms/genetics/pathology
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Transfection
EDAT- 1995/11/15 00:00
MHDA- 1995/11/15 00:01
CRDT- 1995/11/15 00:00
PHST- 1995/11/15 00:00 [pubmed]
PHST- 1995/11/15 00:01 [medline]
PHST- 1995/11/15 00:00 [entrez]
AID - S0006-4971(20)63214-1 [pii]
PST - ppublish
SO  - Blood. 1995 Nov 15;86(10):3655-9.