PMID- 7579911
OWN - NLM
STAT- MEDLINE
DCOM- 19951215
LR  - 20191023
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 9
IP  - 3
DP  - 1995 May-Jun
TI  - Effects observed on gestational day 13 in rat embryos exposed to albendazole.
PG  - 265-73
AB  - Albendazole (ABZ) was utilized as a model to investigate the pathogenesis of 
      benzimidazole-induced abnormalities. Pregnant Sprague-Dawley rats were treated po 
      with 0, 10, 20, and 30 mg/kg on gestational days (GD) 10 to 12. The embryos were 
      examined on GD 13, as a window for observing the origin of alterations detected 
      at term. Embryolethality and growth reduction showed dose-related increases at 
      the three dose levels. At 10 mg/kg, an increased developmental delay of limb buds 
      and a less than 5% incidence of embryos with abnormal head or shape were 
      detected. At 20 and 30 mg/kg, > 20% of embryos showed morphologic alterations 
      involving mainly shape abnormalities and the development of forelimb buds, 
      branchial bars, eye, and telencephalon; closure of neuropores was unaffected. 
      Dose-response relationships for morphologic alterations showed steeper slopes 
      than for growth reduction and embryolethality.
FAU - Mantovani, A
AU  - Mantovani A
AD  - Laboratorio di Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di 
      Sanita, Rome, Italy.
FAU - Ricciardi, C
AU  - Ricciardi C
FAU - Stazi, A V
AU  - Stazi AV
FAU - Macri, C
AU  - Macri C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Teratogens)
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Albendazole/*toxicity
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Embryo Loss/chemically induced
MH  - Embryonic and Fetal Development/*drug effects
MH  - Female
MH  - Gestational Age
MH  - Heart/drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Teratogens/*toxicity
MH  - Yolk Sac/drug effects
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 089062389500008X [pii]
AID - 10.1016/0890-6238(95)00008-x [doi]
PST - ppublish
SO  - Reprod Toxicol. 1995 May-Jun;9(3):265-73. doi: 10.1016/0890-6238(95)00008-x.