PMID- 758102 OWN - NLM STAT- MEDLINE DCOM- 19790126 LR - 20190623 IS - 0009-7322 (Print) IS - 0009-7322 (Linking) VI - 59 IP - 1 DP - 1979 Jan TI - Spontaneous course of ST-segment elevation in acute anterior myocardial infarction. PG - 105-12 AB - The spontaneous course of ST-segment elevation (sigmaST) in 24 patients with acute anterior myocardial infarction (AMI) was studied by precordial ST-segment mapping, which was recorded at 2-hour intervals during the first 48 hours after admission. Change of sigmaST between two registrations was expressed as mV/hr, and was compared with clinical and hemodynamic parameters, course of MB-CK curve, calculated infarct mass and arrhythmias. After an initial rapid increase, there was a decrease of sigmaST, which reaches a plateau-like curve approximately 12 hours after the onset of chest pain. A second new increase of sigmaST exceeding a value of 0.6 mV/hr correlates well with extension of necrosis, verified by re-elevation of MB-CK. During the first 2 days, extension of necrosis could be detected in 50% of our patients. As new ischemic episodes and extension of necrosis in AMI occur frequently and are promptly indicated by an increase of sigmaST, the physician should, while monitoring therapeutic interventions, concentrate on such a second increase rather than on a decrease of sigmaST (which may occur spontaneously), as has been suggested in most previous reports. FAU - Essen, R AU - Essen R FAU - Merx, W AU - Merx W FAU - Effert, S AU - Effert S LA - eng PT - Journal Article PL - United States TA - Circulation JT - Circulation JID - 0147763 SB - IM MH - Adult MH - Aged MH - Arrhythmias, Cardiac/etiology MH - Blood Pressure MH - Electrocardiography MH - Female MH - Heart Conduction System/*physiopathology MH - Heart Rate MH - Humans MH - Male MH - Middle Aged MH - Myocardial Infarction/complications/*diagnosis/physiopathology MH - Necrosis EDAT- 1979/01/01 00:00 MHDA- 1979/01/01 00:01 CRDT- 1979/01/01 00:00 PHST- 1979/01/01 00:00 [pubmed] PHST- 1979/01/01 00:01 [medline] PHST- 1979/01/01 00:00 [entrez] AID - 10.1161/01.cir.59.1.105 [doi] PST - ppublish SO - Circulation. 1979 Jan;59(1):105-12. doi: 10.1161/01.cir.59.1.105.