PMID- 7582288
OWN - NLM
STAT- MEDLINE
DCOM- 19951206
LR  - 20201209
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 152
IP  - 5 Pt 1
DP  - 1995 Nov
TI  - Lymphatic release of cytokines during acute lung injury complicating severe 
      pancreatitis.
PG  - 1527-33
AB  - In severe acute pancreatitis (SAP), the mechanisms leading to adult respiratory 
      distress syndrome (ARDS) are usually attributed to the release of active enzymes 
      and vasoactive substances from the pancreas. Thoracic duct drainage has been 
      proposed as a means of removing the portion of these substances that drain 
      through retroperitoneal lymphatics before they reach the systemic circulation. 
      This technique was used in six patients with ARDS complicating SAP. The levels of 
      proinflammatory cytokines (tumor necrosis factor-alpha [TNF alpha], interleukin-1 
      [IL-1], and interleukin-6 [IL-6]), neutrophil enzymes (myeloperoxidase and 
      lactoferrin), and pancreatic enzymes (amylase, lipase and trypsin) were measured 
      in plasma and lymph in the first 24 h of ARDS and then on Day 2, Day 4, and at 
      the end of the drainage (Day 8). High plasma concentrations of these products 
      were measured. A moderate lymph-to-plasma gradient was observed for IL-6, lipase, 
      and trypsin, while similar levels in plasma and lymph were recorded for the other 
      substances. Plasma levels of pancreatic enzymes were weakly correlated with the 
      lung injury score and lymph level of cytokines. These results suggest that in 
      patients with ARDS due to SAP, cytokines as well as pancreatic enzymes could 
      contribute to the development of the lung injury, and that lymphatics are 
      potential vectors of these mediators.
FAU - Montravers, P
AU  - Montravers P
AD  - Departement d'Anesthesie Reanimation Chirurgicale, Hopital Bichat, Paris, France.
FAU - Chollet-Martin, S
AU  - Chollet-Martin S
FAU - Marmuse, J P
AU  - Marmuse JP
FAU - Gougerot-Pocidalo, M A
AU  - Gougerot-Pocidalo MA
FAU - Desmonts, J M
AU  - Desmonts JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Cytokines)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Cytokines/*analysis
MH  - Female
MH  - Humans
MH  - Lymph/*chemistry
MH  - Male
MH  - Middle Aged
MH  - Neutrophils/enzymology
MH  - Pancreas/enzymology
MH  - Pancreatitis/*complications/metabolism
MH  - Prospective Studies
MH  - Respiratory Distress Syndrome/etiology/*metabolism
MH  - Statistics, Nonparametric
MH  - Thoracic Duct
MH  - Time Factors
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1164/ajrccm.152.5.7582288 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1527-33. doi: 
      10.1164/ajrccm.152.5.7582288.