PMID- 7582299
OWN - NLM
STAT- MEDLINE
DCOM- 19951206
LR  - 20061115
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 152
IP  - 5 Pt 1
DP  - 1995 Nov
TI  - Elevated serum hepatocyte growth factor/scatter factor levels in inflammatory 
      lung disease.
PG  - 1587-91
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) plays an important role in 
      tissue repair in liver and renal damage. The clinical significance of this growth 
      factor in these diseases has also been reported. The lung is one of the major 
      sources of HGF/SF; because of this, we investigated serum HGF/SF levels in 26 
      patients with inflammatory lung disease (15 with interstitial pneumonitis [IP], 
      11 with bacterial pneumonia [BP]) by enzyme-linked immunosorbent assay. As 
      controls, we measured HGF/SF in the serum of 13 stable outpatients with chronic 
      respiratory failure. All patients had no significant liver or renal dysfunction. 
      Serum HGF/SF levels were significantly elevated in patients with IP (1.16 +/- 
      0.22 ng/ml) or BP (0.96 +/- 0.27 ng/ml) compared with those in the control 
      subjects (0.29 +/- 0.03 ng/ml, both p < 0.01). Serum HGF/SF levels in 14 healthy 
      subjects were also studied, and the results (0.30 +/- 0.02 ng/ml) were not 
      remarkably different from those of the control subjects. There were no 
      significant correlations between serum HGF/SF levels and C-reactive protein and 
      lactate dehydrogenase. Serum HGF/SF levels in the surviving patients rapidly 
      decreased with treatment, but they did not change in the patients who ultimately 
      died. Our results demonstrate the clinical significance of serum HGF/SF level as 
      a useful indicator of prognosis in inflammatory lung disease.
FAU - Maeda, J
AU  - Maeda J
AD  - Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
FAU - Ueki, N
AU  - Ueki N
FAU - Hada, T
AU  - Hada T
FAU - Higashino, K
AU  - Higashino K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - C-Reactive Protein/analysis/drug effects
MH  - Chromatography, Affinity/instrumentation/methods/statistics & numerical data
MH  - Chronic Disease
MH  - Enzyme-Linked Immunosorbent Assay/instrumentation/methods/statistics & numerical 
      data
MH  - Hepatocyte Growth Factor/*blood
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood/drug effects
MH  - Lung Diseases, Interstitial/*blood/drug therapy
MH  - Middle Aged
MH  - Pneumonia, Bacterial/*blood/drug therapy
MH  - Statistics, Nonparametric
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1164/ajrccm.152.5.7582299 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1587-91. doi: 
      10.1164/ajrccm.152.5.7582299.