PMID- 7585180
OWN - NLM
STAT- MEDLINE
DCOM- 19951228
LR  - 20190913
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 1
IP  - 8
DP  - 1995 Aug
TI  - Marked amelioration of established collagen-induced arthritis by treatment with 
      antibodies to CD23 in vivo.
PG  - 781-5
AB  - CD23 is a low-affinity receptor for immunoglobulin E (IgE) expressed by a variety 
      of haematopoietic cells. Proteolytic cleavage of the transmembrane receptor 
      generates soluble forms, which can be detected in biological fluids. CD23 
      regulates many functional aspects of immune cells, both in its cell-associated 
      and soluble forms. In view of the increased levels of CD23 in rheumatoid 
      arthritis, we have studied the effect of neutralizing CD23 in type II 
      collagen-induced arthritis in mice, a model for human rheumatoid arthritis. 
      Successful disease modulation is achieved by treatment of arthritic DBA/1 mice 
      with either polyclonal or monoclonal antibodies to mouse CD23. Treated mice show 
      a dose-related amelioration of arthritis with significantly reduced clinical 
      scores and number of affected paws. This improvement in clinical severity is 
      confirmed by histological examination of the arthritic paws. A marked decrease in 
      cellular infiltration of the synovial sublining layer and limited destruction of 
      cartilage and bone is evident in animals treated with therapeutic doses of 
      anti-CD23 antibody. These findings demonstrate the involvement of CD23 in a mouse 
      model of human rheumatoid arthritis.
FAU - Plater-Zyberk, C
AU  - Plater-Zyberk C
AD  - Glaxo Institute for Molecular Biology, Immunology Department, Geneva, 
      Switzerland.
FAU - Bonnefoy, J Y
AU  - Bonnefoy JY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, IgE)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/therapeutic use
MH  - Arthritis, Experimental/therapy
MH  - Arthritis, Rheumatoid/pathology/*therapy
MH  - Collagen
MH  - Disease Models, Animal
MH  - Extremities/pathology
MH  - Humans
MH  - Immunoglobulin G/*therapeutic use
MH  - Immunotherapy/*methods
MH  - Joints/pathology
MH  - Mice
MH  - Mice, Inbred DBA
MH  - Neutralization Tests
MH  - Receptors, IgE/*immunology
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 10.1038/nm0895-781 [doi]
PST - ppublish
SO  - Nat Med. 1995 Aug;1(8):781-5. doi: 10.1038/nm0895-781.