PMID- 7585460
OWN - NLM
STAT- MEDLINE
DCOM- 19951127
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 96
IP  - 2
DP  - 1995 Sep 25
TI  - Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in 
      glandular stomach of analbuminemic rats.
PG  - 219-24
AB  - The susceptibility of pepsinogen-altered pyloric glands (PAPG) and neoplastic 
      glandular stomach lesions induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) 
      and catechol or sodium cholate in Nagase analbuminemic rats (NAR) was compared to 
      Sprague-Dawley rats (SD). Male NAR and SD rats were given a single dose of 80 
      mg/kg body weight of MNNG by gastric intubation and, 2 weeks later, fed basal 
      diet containing 0.8% catechol or 0.3% sodium cholate for 18 weeks. The animals 
      were killed at the end of week 20 or after maintenance on basal diet at week 60. 
      The number of pepsinogen-altered pyloric glands at week 20 was significantly (P < 
      0.001) higher in NAR fed either catechol or sodium cholate compared with SD rats. 
      At week 60, adenomatous hyperplasias and adenocarcinomas were observed in 7 (88%; 
      P < 0.01) and 3 (38%; P < 0.01) of 8 NAR fed catechol and in 4 (22%) and 0 of 18 
      SD rats, respectively. The results show that the frequency of PAPG in NAR and SD 
      rats is related to the susceptibility to glandular stomach carcinoma. PAPG is a 
      useful endpoint lesion for evaluation of gastric carcinogenicity in a 20-week 
      carcinogenicity test, and NAR are sensitive for glandular stomach carcinogenesis.
FAU - Ogawa, K
AU  - Ogawa K
AD  - First Department of Pathology, Nagoya City University Medical School, Japan.
FAU - Shichino, Y
AU  - Shichino Y
FAU - Tatematsu, M
AU  - Tatematsu M
FAU - Furihata, C
AU  - Furihata C
FAU - Asamoto, M
AU  - Asamoto M
FAU - Nagase, S
AU  - Nagase S
FAU - Shirai, T
AU  - Shirai T
FAU - Ito, N
AU  - Ito N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Carcinogens)
RN  - 0 (Catechols)
RN  - 0 (Cholic Acids)
RN  - 0 (Pepsinogens)
RN  - 0 (Serum Albumin)
RN  - 12H3O2UGSF (Methylnitronitrosoguanidine)
RN  - G1JO7801AE (Cholic Acid)
RN  - LF3AJ089DQ (catechol)
SB  - IM
MH  - Adenocarcinoma/chemically induced/*pathology
MH  - Animals
MH  - Carcinogens
MH  - Catechols/*toxicity
MH  - Cholic Acid
MH  - Cholic Acids/*toxicity
MH  - Gastric Mucosa/*drug effects/enzymology/pathology
MH  - Hyperplasia
MH  - Male
MH  - Methylnitronitrosoguanidine
MH  - Pepsinogens/*metabolism
MH  - Pyloric Antrum
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Rats, Sprague-Dawley
MH  - Serum Albumin/*deficiency/genetics
MH  - Species Specificity
MH  - Stomach Neoplasms/chemically induced/*pathology
EDAT- 1995/09/25 00:00
MHDA- 1995/09/25 00:01
CRDT- 1995/09/25 00:00
PHST- 1995/09/25 00:00 [pubmed]
PHST- 1995/09/25 00:01 [medline]
PHST- 1995/09/25 00:00 [entrez]
AID - 030438359503935P [pii]
AID - 10.1016/0304-3835(95)03935-p [doi]
PST - ppublish
SO  - Cancer Lett. 1995 Sep 25;96(2):219-24. doi: 10.1016/0304-3835(95)03935-p.