PMID- 7586412
OWN - NLM
STAT- MEDLINE
DCOM- 19951228
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 92
IP  - 9 Suppl
DP  - 1995 Nov 1
TI  - Peak oxygen consumption and resting left ventricular ejection fraction changes 
      after cardiomyoplasty at 6-month follow-up.
PG  - II216-22
AB  - BACKGROUND: The effects of cardiomyoplasty on cardiopulmonary exercise test 
      characteristics are not fully known. METHODS AND RESULTS: We determined in 19 
      patients who underwent cardiomyoplasty for treatment of refractory heart failure 
      (New York Heart Association [NYHA] functional class III) before (pre) and at 
      6-month follow-up (post) maximum oxygen consumption (peak VO2), NYHA functional 
      class, and resting left ventricular ejection fraction (LVEF) (MUGA). We analyzed 
      the results according to pre peak VO2 < or > 14 mL/kg per minute and the 
      correlation between the changes in absolute values of LVEF and peak VO2. Pre- and 
      post-peak VO2 values were 15.9 +/- 4.4 and 18.6 +/- 6.4 mL/kg per minute, 
      respectively (P = .059). In the subgroup with pre-peak VO2 < 14 mL/kg per minute, 
      the peak VO2 increased from 11.1 +/- 1.9 to 16.4 +/- 6.2 mL/kg per minute (P = 
      .02). The subgroup with peak VO2 > 14 mL/kg per minute showed pre- and post-peak 
      VO2 of 19.2 +/- 2.6 and of 20.1 +/- 7 mL/kg per minute, respectively (P = .06). 
      The pre-total exercise time of the entire group increased from 688.4 +/- 222.1 to 
      833.7 +/- 241.6 seconds (P < .04). For the subgroup with preoperative peak VO2 < 
      14 mL/kg per minute, exercise time improved from 585 +/- 76.9 to 825 +/- 186.3 
      seconds (P < .01). In the subgroup with preoperative VO2 > 14 mL/kg per minute, 
      the preexercise and postexercise time was 763.6 +/- 264.4 and 840 +/- 282 
      seconds, respectively (P = .4). Pre-LVEF increased from 20.6 +/- 3.3% to 24.2 +/- 
      7.8% at 6 months of follow-up (P = .02). At 6 months of follow-up, 9 patients 
      were in NYHA functional class I and 10 were in class II. There was no correlation 
      between LVEF values and absolute values of peak VO2 before (r = .123, P = .6) and 
      after (r = .27, P = .2) cardiomyoplasty. A weak correlation was observed between 
      the changes in absolute values of peak VO2 and LVEF from the preoperative to the 
      postoperative period (r = .48, P = .048). CONCLUSIONS: Cardiomyoplasty is a 
      useful method for improving NYHA functional class and LVEF in patients with heart 
      failure. Peak VO2 < 14 mL/kg per minute before cardiomyoplasty may be a selection 
      criterion with which to determine improved exercise capacity after surgery. The 
      effects of cardiomyoplasty on LVEF appear to be partially associated with maximum 
      exercise capacity changes.
FAU - Bocchi, E A
AU  - Bocchi EA
AD  - Heart Institute, Sao Paulo (Brazil), University Medical School.
FAU - Guimaraes, G V
AU  - Guimaraes GV
FAU - Moreira, L F
AU  - Moreira LF
FAU - Bacal, F
AU  - Bacal F
FAU - de Moraes, A V
AU  - de Moraes AV
FAU - Barreto, A C
AU  - Barreto AC
FAU - Wajngarten, M
AU  - Wajngarten M
FAU - Bellotti, G
AU  - Bellotti G
FAU - Stolf, N
AU  - Stolf N
FAU - Jatene, A
AU  - Jatene A
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Adult
MH  - *Cardiomyoplasty
MH  - Exercise Test
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*physiopathology/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxygen Consumption
MH  - *Stroke Volume
MH  - Ventricular Function, Left
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1161/01.cir.92.9.216 [doi]
PST - ppublish
SO  - Circulation. 1995 Nov 1;92(9 Suppl):II216-22. doi: 10.1161/01.cir.92.9.216.