PMID- 7586542
OWN - NLM
STAT- MEDLINE
DCOM- 19951214
LR  - 20190722
IS  - 0009-9147 (Print)
IS  - 0009-9147 (Linking)
VI  - 41
IP  - 11
DP  - 1995 Nov
TI  - Fluorescence in situ hybridization: powerful molecular tool for cancer prognosis.
PG  - 1554-9
AB  - We review several aspects of fluorescence in situ hybridization (FISH) technology 
      that demonstrate its breadth and power in detecting and monitoring genetic 
      abnormalities associated with cancers. The clinical utility of FISH in disease 
      management is demonstrated in several examples, including trisomy 8 detection 
      with high specificity and sensitivity in patients with myeloid leukemias; trisomy 
      12 detection with higher efficiency than conventional cytogenetics in patients 
      with chronic lymphocytic leukemia; assessment of engraftment success, chimerism, 
      and relapse in opposite sex bone marrow transplantation; and correlation of 
      trisomy 7 with survival time in patients with prostate tumors. Advances in FISH 
      technology include multicolor analyses, which permit the simultaneous detection 
      of several genetic abnormalities by using cohybridization of probes labeled with 
      several fluorescent labels or label combinations, and comparative genomic 
      hybridization, a relatively new method whereby a single hybridization can reveal 
      aberrations across the entire genome.
FAU - Fox, J L
AU  - Fox JL
FAU - Hsu, P H
AU  - Hsu PH
FAU - Legator, M S
AU  - Legator MS
FAU - Morrison, L E
AU  - Morrison LE
FAU - Seelig, S A
AU  - Seelig SA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
SB  - IM
MH  - *Chromosome Aberrations
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence/methods
MH  - Leukemia/genetics
MH  - Neoplasms/*genetics
MH  - Prognosis
MH  - Trisomy
RF  - 11
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
PST - ppublish
SO  - Clin Chem. 1995 Nov;41(11):1554-9.