PMID- 7587397
OWN - NLM
STAT- MEDLINE
DCOM- 19951124
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 71
IP  - 3
DP  - 1995
TI  - Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein 
      gene (ITIHL1) to human chromosome 3p21-->p14.
PG  - 296-8
AB  - Inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) is a 
      novel glycoprotein isolated from human plasma. The cDNA encoding IHRP has 
      recently been cloned from human liver cDNA libraries. We report the mapping of 
      this gene (ITIHL1) by fluorescence in situ hybridization using a 2.5-kb cDNA 
      fragment as a probe. ITIHL1 was localized to chromosome region 3p21-->p14 where 
      the genes of heavy chain 1 and 3 of inter-alpha-trypsin inhibitor are located. 
      This result, together with significant homology between the nucleotide sequences 
      of ITIHL1 and the heavy chain genes, supports ITIHL1 as being a member of an 
      evolutionary related gene family of ITI heavy chains. Northern blot analysis 
      indicated that IHRP was predominantly synthesized in liver. From Southern blot 
      analysis, it was tentatively concluded that ITIHL1 is a single copy gene.
FAU - Tobe, T
AU  - Tobe T
AD  - Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa 
      University, Tokyo, Japan.
FAU - Saguchi, K
AU  - Saguchi K
FAU - Hashimoto, K
AU  - Hashimoto K
FAU - Miura, N H
AU  - Miura NH
FAU - Tomita, M
AU  - Tomita M
FAU - Li, F
AU  - Li F
FAU - Wang, Y
AU  - Wang Y
FAU - Minoshima, S
AU  - Minoshima S
FAU - Shimizu, N
AU  - Shimizu N
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Blood Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Glycoproteins)
RN  - 0 (ITIH4 protein, human)
RN  - 0 (Proteinase Inhibitory Proteins, Secretory)
SB  - IM
MH  - Blood Proteins/*genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 3
MH  - DNA, Complementary
MH  - Glycoproteins/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Proteinase Inhibitory Proteins, Secretory
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1159/000134130 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1995;71(3):296-8. doi: 10.1159/000134130.