PMID- 7589400
OWN - NLM
STAT- MEDLINE
DCOM- 19951207
LR  - 20190821
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 8
IP  - 7
DP  - 1995 Jul
TI  - Eosinophil cationic protein and tidal flow volume loops in children 0-2 years of 
      age.
PG  - 1148-54
AB  - Many children with recurrent wheezing in early childhood develop asthma. 
      Objective parameters to describe different groups of wheezers are limited, but 
      tidal flow volume (TFV) response to inhaled salbutamol has demonstrated 
      differences between children with and without asthma. Also, eosinophil cationic 
      protein (ECP) has been associated with declining lung function in older children. 
      We therefore investigated whether lung function and serum ECP (s-ECP) could 
      differentiate between groups of wheezy young children. TFV loops were measured in 
      79 awake children (mean age 14 months). Minimum two wheezy episodes (mean 3.2) or 
      minimum 4 weeks persistent wheeze were reported in 41 children (cases), whereas 
      the 38 controls had no history of wheeze. Airways responsiveness (change in ratio 
      of time until peak expiratory flow to total expiratory time (tPEF/tE) after 
      inhaled nebulized salbutamol) was measured in 26 cases and 24 controls. Serum ECP 
      and serum myeloperoxidase (s-MPO) were measured in all children. Cases had 
      significantly lower mean tPEF/tE (0.21) than controls (0.33), and higher mean 
      s-ECP (21.9 micrograms.L-1) than controls (14.0 micrograms.L-1). Serum ECP (but 
      not s-MPO) correlated significantly with the percentage change in tPEF/tE from 
      baseline (r = 0.7), but not with initial tPEF/tE. Serum ECP increased 
      significantly with increasing immunoglobulin E (IgE), airways responsiveness and 
      eosinophil count, but decreased with increasing age. TFV responsiveness to 
      salbutamol and s-ECP levels correlate strongly, both probably reflecting airways 
      inflammation, and may possibly be valuable prognostic tools in recurrent wheezy 
      infants and toddlers.
FAU - Lodrup Carlsen, K C
AU  - Lodrup Carlsen KC
AD  - Paediatric Dept, Ulleval Hospital, Oslo, Norway.
FAU - Halvorsen, R
AU  - Halvorsen R
FAU - Ahlstedt, S
AU  - Ahlstedt S
FAU - Carlsen, K H
AU  - Carlsen KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Blood Proteins)
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 0 (Inflammation Mediators)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.1.- (Ribonucleases)
RN  - QF8SVZ843E (Albuterol)
SB  - IM
MH  - Albuterol
MH  - Asthma/blood/*diagnosis/physiopathology
MH  - Blood Proteins/*analysis
MH  - Bronchial Provocation Tests
MH  - Bronchodilator Agents
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Eosinophil Granule Proteins
MH  - Female
MH  - Humans
MH  - Infant
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Maximal Expiratory Flow-Volume Curves/physiology
MH  - Peroxidase/blood
MH  - Prognosis
MH  - Reference Values
MH  - Respiratory Sounds/*diagnosis/physiopathology
MH  - *Ribonucleases
MH  - Tidal Volume/physiology
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1183/09031936.95.08071148 [doi]
PST - ppublish
SO  - Eur Respir J. 1995 Jul;8(7):1148-54. doi: 10.1183/09031936.95.08071148.