PMID- 7589833
OWN - NLM
STAT- MEDLINE
DCOM- 19951129
LR  - 20221207
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 44
IP  - 11
DP  - 1995 Nov
TI  - Residual beta-cell function and HLA-A24 in IDDM. Markers of glycemic control and 
      subsequent development of diabetic retinopathy.
PG  - 1334-9
AB  - To identify risk factors for diabetic retinopathy in insulin-dependent diabetes 
      mellitus (IDDM), we studied the relationships among residual beta-cell function, 
      human leukocyte antigen (HLA), long-term glycemic control, and development of 
      diabetic retinopathy in 128 IDDM patients. Residual beta-cell function was 
      assessed by serum C-peptide immunoreactivity (CPR) response to a 100-g oral 
      glucose load (delta CPR). The patients were stratified into three groups: those 
      with delta CPR of < 0.033 nmol/l (group 1, n = 50), those with delta CPR of 
      0.033-0.1 nmol/l (group 2, n = 38), and those with delta CPR of > 0.1 nmol/l 
      (group 3, n = 40). The cumulative incidence rate of background retinopathy was 
      higher in the order of groups 1, 2, and 3 (P = 0.032). Group 1 progressed to 
      preproliferative retinopathy at an earlier stage than did groups 2 and 3 combined 
      (P = 0.028). Further progression to proliferative retinopathy tended to be 
      earlier in group 1 than in groups 2 and 3 combined (P = 0.083). The mean HbA1c 
      value rose from 9.01 +/- 1.06% (mean +/- SD) in group 3 to 9.75 +/- 0.79% in 
      group 2 to 10.48 +/- 1.12% in group 1 (P < 0.0001). In group 1, 89.6% of the 
      patients had HLA-A24, whereas 50 and 43.6% of the patients had this antigen in 
      groups 2 and 3 respectively (P < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Nakanishi, K
AU  - Nakanishi K
AD  - Department of Endocrinology and Metabolism, Okinaka Memorial Institute for 
      Medical Research, Tokyo, Japan.
FAU - Kobayashi, T
AU  - Kobayashi T
FAU - Inoko, H
AU  - Inoko H
FAU - Tsuji, K
AU  - Tsuji K
FAU - Murase, T
AU  - Murase T
FAU - Kosaka, K
AU  - Kosaka K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A24 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - C-Peptide/*blood
MH  - Child
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/immunology/*physiopathology
MH  - Diabetic Retinopathy/*epidemiology/immunology/*physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/analysis
MH  - HLA-A Antigens/*blood
MH  - HLA-A24 Antigen
MH  - Histocompatibility Testing
MH  - Humans
MH  - Incidence
MH  - Islets of Langerhans/immunology/*physiopathology
MH  - Life Tables
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Time Factors
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.2337/diab.44.11.1334 [doi]
PST - ppublish
SO  - Diabetes. 1995 Nov;44(11):1334-9. doi: 10.2337/diab.44.11.1334.