PMID- 7590833
OWN - NLM
STAT- MEDLINE
DCOM- 19951206
LR  - 20151119
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 47
IP  - 2
DP  - 1995 Mar-Apr
TI  - Evidence for free-radical mediated injury during coronary artery bypass surgery.
PG  - 107-11
AB  - Prolonged global ischemia followed by reperfusion during coronary artery bypass 
      graft (CABG) surgery leads to a burst of oxygen free-radical generation and 
      subsequent myocardial impairment. Blood samples were collected at different time 
      periods from the right atrium of patients (n = 55) who underwent CABG surgery. 
      Free-radical activity was measured by assays for thiobarbituric acid reactive 
      species (TBARS), mainly malondialdehyde (MDA), at zero minute (before aortic 
      cross-clamp), one minute and 10 minutes after declamping i.e. reperfusion. There 
      was a significant increase (p < 0.001) in the level of MDA at one minute of 
      reperfusion which continued to be elevated up to 10 minutes. This increase was 
      significantly correlated with aortic cross-clamp time (r = 0.525, p < 0.05). The 
      activity of CPK and CPK-MB was raised by two fold (p < 0.001) after release of 
      the clamp. Plasma Troponin-T level was estimated in 10 patients during CABG 
      surgery and a significant increase (p < 0.01) was observed at one minute as well 
      as 10 minutes of reperfusion which correlated well (r = 0.81, p < 0.01) with the 
      severity of ischemia. The concomitant rise in TBARS (marker of free-radical 
      activity), CPK, CPK-MB and Troponin-T (indicators of myocardial damage) on 
      reperfusion implies that there is free-radical mediated damage to the cardiac 
      membrane during CABG surgery.
FAU - Movahed, A
AU  - Movahed A
AD  - PD Hinduja National Hospital & Medical Research Centre, Bombay.
FAU - Nair, K G
AU  - Nair KG
FAU - Ashavaid, T F
AU  - Ashavaid TF
FAU - Kumar, P
AU  - Kumar P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
RN  - 0 (Biomarkers)
RN  - 0 (Isoenzymes)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (Troponin)
RN  - 0 (Troponin T)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
CIN - Indian Heart J. 1995 Mar-Apr;47(2):112-3. PMID: 7590834
MH  - Biomarkers/blood
MH  - Coronary Artery Bypass/*adverse effects
MH  - Creatine Kinase/blood
MH  - Female
MH  - Humans
MH  - Isoenzymes
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*metabolism
MH  - *Myocardial Reperfusion Injury
MH  - Reactive Oxygen Species/*metabolism
MH  - Thiobarbituric Acid Reactive Substances/analysis
MH  - Troponin/blood
MH  - Troponin T
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
PST - ppublish
SO  - Indian Heart J. 1995 Mar-Apr;47(2):107-11.