PMID- 759197
OWN - NLM
STAT- MEDLINE
DCOM- 19790328
LR  - 20190623
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 53
IP  - 2
DP  - 1979 Jan 1
TI  - Effects of chemical sympathectomy on hypertension and stroke in stroke-prone 
      spontaneously hypertensive rats.
PG  - 173-9
AB  - Neonates of male stroke-prone spontaneously hypertensive rats (SHRSP) were 
      treated with 6-hydroxydopamine (6-OHDA) on two different schedules. Peripheral 
      sympathectomy, which was evaluated by the pressor response to exogenous 
      noradrenaline (NA) or by the decrease in NA content of the spleen, was more 
      evident in the NB-8 group (treated on 8th and 15th day after birth) than in the 
      NB-1 group (treated at 6, 24 and 72 h after birth). The reduction of the NA 
      content in the cerebral cortex was more prominent in the NB-1 group than in the 
      NB-8 group. The blood pressure from 7 to 23 weeks of age was lower in the treated 
      groups: NB-8 less than NB-1 less than control. Therefore, the reduction of blood 
      pressure in the treated groups could be related to the severity of peripheral 
      sympathectomy. The incidence of sroke was also lower in the treated groups: 38, 
      11 and 0% in the control NB-1 and NB-8 groups, respectively. Loading with 1% NaCl 
      solution from 11 weeks of age enhanced the rise in blood pressure and increased 
      the incidence of stroke in each group of rats: 100, 20 and 40% in the control. 
      NB-1 and NB-8 groups, respectively. However, the onset of stroke after exhibiting 
      a severe hypertension (greater than 200 mmHg) was delayed in the treated groups. 
      It seems that the activated tone in the peripheral sympathetic nerve is likely to 
      participate in the development of spontaneous hypertension. In addition to the 
      high blood pressure level, the activated tone of sympathetic nerve innervating 
      the cerebral vasculature may be partly involved in the development of stroke in 
      the new strain of the SHR rats, SHRSP.
FAU - Ikeda, H
AU  - Ikeda H
FAU - Shino, A
AU  - Shino A
FAU - Nagaoka, A
AU  - Nagaoka A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Hydroxydopamines)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Body Weight/drug effects
MH  - Cerebral Cortex/analysis
MH  - Cerebrovascular Disorders/*etiology/physiopathology
MH  - Hydroxydopamines/*pharmacology
MH  - Hypertension/*etiology/physiopathology
MH  - Male
MH  - Norepinephrine/analysis
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sodium Chloride/adverse effects
MH  - Spleen/analysis
MH  - Sympathetic Nervous System/*drug effects/physiopathology
EDAT- 1979/01/01 00:00
MHDA- 1979/01/01 00:01
CRDT- 1979/01/01 00:00
PHST- 1979/01/01 00:00 [pubmed]
PHST- 1979/01/01 00:01 [medline]
PHST- 1979/01/01 00:00 [entrez]
AID - 0014-2999(79)90163-8 [pii]
AID - 10.1016/0014-2999(79)90163-8 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1979 Jan 1;53(2):173-9. doi: 10.1016/0014-2999(79)90163-8.