PMID- 7594679
OWN - NLM
STAT- MEDLINE
DCOM- 19951228
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 172
IP  - 5
DP  - 1995 Nov
TI  - Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in 
      patients with chronic fatigue syndrome.
PG  - 1364-7
AB  - To evaluate the association between human herpesvirus 6 (HHV-6) and chronic 
      fatigue syndrome (CFS), 2 geographically separate groups of CFS patients (125 and 
      29 patients, respectively) and healthy controls (150 and 15 controls, 
      respectively) were compared, using an EIA, for antibodies to HHV-6 early antigen 
      p41/38 (EA). Sixty percent (93/154) of CFS patients were were positive for HHV-6 
      EA IgM, 40% (61/154) were positive for IgG, and 23% (35/154) were positive for 
      both. A total of 119 (77%) of the CFS patients were positive for HHV-6 EA IgG or 
      IgM (or both); only 12% (20/165) of the controls had IgG or IgM to HHV-6 EA. 
      These data demonstrate that more CFS patients than controls had elevated levels 
      of HHV-6 EA-specific IgM, perhaps indicating active replication of HHV-6 in CFS.
FAU - Patnaik, M
AU  - Patnaik M
AD  - Specialty Laboratories, Inc., Santa Monica, California 90404-3900, USA.
FAU - Komaroff, A L
AU  - Komaroff AL
FAU - Conley, E
AU  - Conley E
FAU - Ojo-Amaize, E A
AU  - Ojo-Amaize EA
FAU - Peter, J B
AU  - Peter JB
LA  - eng
GR  - AI-32246/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Viral Proteins)
RN  - 138415-18-6 (p41 protein, Human herpesvirus 6)
SB  - IM
EIN - J Infect Dis 1995 Dec;172(6):1643
MH  - Antibodies, Viral/*blood
MH  - Antibody Specificity
MH  - DNA-Binding Proteins/*immunology
MH  - Fatigue Syndrome, Chronic/*immunology/*virology
MH  - Herpesviridae Infections/*immunology
MH  - *Herpesvirus 6, Human/immunology
MH  - Humans
MH  - Immunoglobulin M/*blood
MH  - Reference Values
MH  - Viral Proteins/*immunology
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1093/infdis/172.5.1364 [doi]
PST - ppublish
SO  - J Infect Dis. 1995 Nov;172(5):1364-7. doi: 10.1093/infdis/172.5.1364.