PMID- 7595529
OWN - NLM
STAT- MEDLINE
DCOM- 19951204
LR  - 20220309
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 65
IP  - 5
DP  - 1995 Nov
TI  - Differential oligodendroglial expression of the tumor necrosis factor receptors 
      in vivo and in vitro.
PG  - 2377-80
AB  - The cytokine tumor necrosis factor-alpha (TNF alpha) has been proposed to play a 
      key role in the degenerative processes observed in demyelinating diseases such as 
      multiple sclerosis (MS). In the immune system the cellular responses to TNF are 
      mediated by two different receptors: TNF-RI, which is involved in cell death, and 
      TNF-RII, which has been shown to mediate cell proliferation. We investigated the 
      oligodendroglial expression of TNF-RI and -RII. In vivo, in normal adult rodent 
      brain, oligodendrocytes express TNF-RII but not TNF-RI. However, after 3 days in 
      culture, both types of receptors were expressed by mature oligodendrocytes, 
      purified from 4-week-old rats, suggesting that expression of TNF-RI was induced 
      by either the isolation process or the culture conditions. This inducibility of 
      TNF-RI may explain the differences in oligodendrocyte cell death reported in 
      various experimental conditions and in the pathology of MS lesions.
FAU - Tchelingerian, J L
AU  - Tchelingerian JL
AD  - INSERM U. 134, Hopital de la Salpetriere, Paris, France.
FAU - Monge, M
AU  - Monge M
FAU - Le Saux, F
AU  - Le Saux F
FAU - Zalc, B
AU  - Zalc B
FAU - Jacque, C
AU  - Jacque C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Molecular Probes)
RN  - 0 (Receptors, Tumor Necrosis Factor)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cells, Cultured
MH  - Immunologic Techniques
MH  - In Situ Hybridization
MH  - Molecular Probes/genetics
MH  - Molecular Sequence Data
MH  - Oligodendroglia/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Tumor Necrosis Factor/*metabolism
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1046/j.1471-4159.1995.65052377.x [doi]
PST - ppublish
SO  - J Neurochem. 1995 Nov;65(5):2377-80. doi: 10.1046/j.1471-4159.1995.65052377.x.