PMID- 7596305
OWN - NLM
STAT- MEDLINE
DCOM- 19950728
LR  - 20190821
IS  - 0306-9877 (Print)
IS  - 0306-9877 (Linking)
VI  - 44
IP  - 2
DP  - 1995 Feb
TI  - Sunlight induced progression of AIDS.
PG  - 119-23
AB  - Ultraviolet B (UVB) radiation in sunlight damages the cutaneous immune system of 
      individuals primarily by converting trans-urocanic acid (UCA) to its cis isoform 
      which in turn instigates excessive local, and eventually systemic, levels of 
      tumor necrosis factor-alpha (TNF alpha). UVB radiation and TNF alpha have been 
      found to activate HIV from the latent state, and TNF alpha has been implicated in 
      the pathogenesis of several manifestations of the acquired immune deficiency 
      syndrome (AIDS). We hypothesize that the immunosuppressant properties of TNF 
      alpha and cis-UCA, released by intense sun exposure, can accelerate the onset and 
      progression of AIDS in HIV-infected individuals.
FAU - Vincek, V
AU  - Vincek V
AD  - Department of Microbiology and Immunology, University of Miami School of 
      Medicine, FL 33101, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Prostaglandins E)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - G8D26XJJ3B (Urocanic Acid)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*physiopathology
MH  - Animals
MH  - Disease Progression
MH  - Epidermis/*immunology/radiation effects
MH  - HIV/growth & development
MH  - Humans
MH  - Immune Tolerance/radiation effects
MH  - Immunocompetence/radiation effects
MH  - Mice
MH  - Models, Immunological
MH  - Prostaglandins E/biosynthesis
MH  - Sunlight/*adverse effects
MH  - Th2 Cells/immunology
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - Ultraviolet Rays/*adverse effects
MH  - Urocanic Acid/radiation effects
MH  - Virus Activation
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 0306-9877(95)90083-7 [pii]
AID - 10.1016/0306-9877(95)90083-7 [doi]
PST - ppublish
SO  - Med Hypotheses. 1995 Feb;44(2):119-23. doi: 10.1016/0306-9877(95)90083-7.