PMID- 7597298
OWN - NLM
STAT- MEDLINE
DCOM- 19950803
LR  - 20190904
IS  - 0080-0015 (Print)
IS  - 0080-0015 (Linking)
VI  - 139
DP  - 1995
TI  - Human leukocyte antigens and multiple basal cell carcinomas.
PG  - 297-302
AB  - This study presents data on human leukocyte antigen (HLA) phenotypes of 49 
      unrelated patients with multiple basal cell carcinomas (five or more BCC). 
      Previous investigators noted an association with HLA-DR1 and a negative 
      association with HLA-DR4. However, the previously found association was weak. HLA 
      typing for class I (HLA-A, -B, -C) and class II antigens (HLA-DR, -DQ) was done 
      from acid citrate dextrose (ACD)-stabilized peripheral blood using the modified 
      lymphocytotoxicity test after T/B cell separation by immunobeads. Antigen 
      frequencies of the patient group were compared to those of healthy individuals of 
      a local German population (n = 716). Chi-square test and Fisher's exact test were 
      used for statistical evaluation. While a significant association with HLA-DR1 was 
      not observed in our study, we were able to confirm a significant decrease of 
      HLA-DR4 in the patient group (12.2% versus 25.1%; p < 0.05; relative risk, RR, 
      0.48). In addition, HLA-Cw7 was significantly increased in the patient group 
      (61.2% versus 40.8%; p < 0.01; RR, 2.29). In a subgroup of patients with multiple 
      BCC located on the trunk (n = 25), the negative association with HLA-DR4 was even 
      stronger (4% versus 25.1%; p < 0.02; RR, 0.12), whereas HLA-Cw7 was not 
      significant (60.0% versus 40.8%; p = 0.06). Our results showed decreased 
      frequencies of HLA-DR4 and increased frequencies of HLA-Cw7 in cases of multiple 
      BCC, although statistical evaluation revealed only a weak association. This might 
      be due to possible heterogeneity in this disease, e.g., BCC of the trunk versus 
      BCC of the face, or any other cofactors.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Rompel, R
AU  - Rompel R
AD  - Department of Dermatology, Municipal Clinics of Kassel, Germany.
FAU - Petres, J
AU  - Petres J
FAU - Kaupert, K
AU  - Kaupert K
FAU - Muller-Eckhardt, G
AU  - Muller-Eckhardt G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Recent Results Cancer Res
JT  - Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans 
      les recherches sur le cancer
JID - 0044671
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antigens, Neoplasm/analysis/genetics
MH  - Carcinoma, Basal Cell/genetics/*immunology
MH  - Disease Susceptibility/immunology
MH  - Facial Neoplasms/genetics/immunology
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*analysis/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunophenotyping
MH  - Neoplasms, Multiple Primary/genetics/*immunology
MH  - Skin Neoplasms/genetics/*immunology
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/978-3-642-78771-3_22 [doi]
PST - ppublish
SO  - Recent Results Cancer Res. 1995;139:297-302. doi: 10.1007/978-3-642-78771-3_22.