PMID- 7598453
OWN - NLM
STAT- MEDLINE
DCOM- 19950728
LR  - 20211203
IS  - 0066-4219 (Print)
IS  - 0066-4219 (Linking)
VI  - 46
DP  - 1995
TI  - Marrow transplantation from unrelated volunteer donors.
PG  - 169-79
AB  - Marrow transplants from human leukocyte antigen (HLA)-compatible unrelated 
      volunteer donors have become feasible for more than 30% of patients without a 
      family match and have allowed long-term, disease-free survival in 15-65% of 
      patients with a variety of hematological disorders. However, unrelated donor 
      transplants have a higher incidence of graft failure and graft versus host 
      disease (GVHD) than do HLA-matched sibling transplants. This increase may be due 
      to disparities between donor and recipient for undetected HLA determinants or for 
      non-HLA histocompatibility genes. Because of the large number of HLA loci and 
      their high degree of polymorphism, fully compatible donors will not be found for 
      most patients. Fortunately, a limited degree of HLA mismatch does not necessarily 
      impair long-term survival in patients with hematologic malignancy. Current 
      studies are defining the risk associated with mismatching for each 
      histocompatibility locus and are developing methods for marrow transplantation 
      that can decrease morbidity and improve survival despite genetic disparity 
      between donor and recipient.
FAU - Anasetti, C
AU  - Anasetti C
AD  - Immunogenetics Program, Fred Hutchinson Cancer Research Center, Seattle, 
      Washington 98104, USA.
FAU - Etzioni, R
AU  - Etzioni R
FAU - Petersdorf, E W
AU  - Petersdorf EW
FAU - Martin, P J
AU  - Martin PJ
FAU - Hansen, J A
AU  - Hansen JA
LA  - eng
GR  - AI 33484/AI/NIAID NIH HHS/United States
GR  - CA 18029/CA/NCI NIH HHS/United States
GR  - CA 18221/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Annu Rev Med
JT  - Annual review of medicine
JID - 2985151R
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Disease-Free Survival
MH  - Graft vs Host Disease/etiology/prevention & control
MH  - HLA Antigens/genetics
MH  - Hematologic Diseases/genetics/*therapy
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Immunosuppression Therapy
MH  - *Tissue Donors
RF  - 26
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1146/annurev.med.46.1.169 [doi]
PST - ppublish
SO  - Annu Rev Med. 1995;46:169-79. doi: 10.1146/annurev.med.46.1.169.