PMID- 7599434
OWN - NLM
STAT- MEDLINE
DCOM- 19950810
LR  - 20061115
IS  - 0213-3911 (Print)
IS  - 0213-3911 (Linking)
VI  - 10
IP  - 2
DP  - 1995 Apr
TI  - Effects of prenatal exposure to low dose ionizing radiation on the development of 
      the cerebellar cortex in the rat.
PG  - 371-83
AB  - The effects of maternal exposure to a single dose of whole body irradiation (0.5 
      Gy) on gestational days (GD) 17, 18, 19, or 20 on the development of the 
      cerebellar cortex was examined in the offspring of Sprague Dawley rats at 21 and 
      28 days postnatally. No gross cerebellar anomalies were observed in the 
      irradiated animals. However, compared to control animals, rat irradiated on each 
      of GD-17, 18, 19 and 20 showed a significantly higher incidence (p < 0.05) of 
      circumscribed cerebellar lesions (CL) distributed in the inner granular layer of 
      the anterior and posterior lobes. These lesions were characterized by a loss of 
      granule cells and atrophied and/or reduced number of Purkinje cells. In 21 days 
      old rats, irradiation on GD-17 resulted in more CL anteriorly (75%) and in the 
      vermis whereas on GD-20, the CL predominated posteriorly (100%) and in the 
      lateral hemispheres. In 28 day old rats, following irradiation on each of GD-17 
      and GD-20, there was an equal distribution of CL in both the anterior and 
      posterior lobes. However, with irradiation on both GD-17 and GD-20, these CL 
      occurred more frequently in the lateral hemispheres of the anterior lobe, whereas 
      in the posterior lobe they predominated in the vermis. These results suggest that 
      a direct relationship exists between the proliferation, migration, development, 
      and maturation of granule cells and their induction by Purkinje cells. The 
      findings also support the view that both cell death and the regulation of granule 
      cells by Purkinje cells maximize the effective development and organization of 
      the cerebellum.
FAU - Ralcewicz, T A
AU  - Ralcewicz TA
AD  - Department of Anatomy, University of Manitoba, Winnipeg, Canada.
FAU - Persaud, T V
AU  - Persaud TV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
SB  - IM
MH  - Animals
MH  - Cell Division/radiation effects
MH  - Cell Movement/radiation effects
MH  - Cerebellar Cortex/cytology/*growth & development/*radiation effects
MH  - Female
MH  - Gestational Age
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Purkinje Cells/radiation effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Whole-Body Irradiation
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
PST - ppublish
SO  - Histol Histopathol. 1995 Apr;10(2):371-83.