PMID- 7599784
OWN - NLM
STAT- MEDLINE
DCOM- 19950809
LR  - 20190920
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 426
IP  - 4
DP  - 1995
TI  - Gene rearrangements and chromosomal translocations in T cell lymphoma--diagnostic 
      applications and their limits.
PG  - 323-38
AB  - The diversity of the T cell receptor (TCR) repertoire is established for 
      individual T lymphocytes by developmentally regulated gene rearrangements and 
      shaped by predominantly intrathymic selection procedures. TCR gene probes in 
      Southern blot experiments and TCR primers for the polymerase chain reaction (PCR) 
      help to distinguish polyclonal from abnormal clonal T cell proliferations and to 
      monitor clonal disease after treatment. Rearrangement studies can identify the 
      lineage and developmental stage of a lymphocyte clone. Cross-lineage 
      rearrangements, false positive or negative results are rarely misleading when 
      morphology and immunophenotypical findings are considered. Rearrangement studies, 
      however, have not contributed significantly to the comprehension of 
      lymphomagenesis. Analyses of characteristic chromosomal translocations in T cell 
      leukaemias and lymphomas may provide further insight into the mechanisms of 
      malignant transformation. Transcription factors are often involved and sometimes 
      abnormally transcribed, which may alter the physiological intracellular 
      signalling in T cells. Interphase cytogenetic analysis by chromosomal 
      fluorescence in situ hybridization (FISH) has become a new tool in the search for 
      transformed T cells carrying specific translocations. Archival biopsy material is 
      now accessible for PCR rearrangement studies and FISH cytogenetics. This adds 
      another dimension to the diagnosis, disease monitoring and biological 
      understanding of malignant T cell lymphomas and leukaemias.
FAU - Griesser, H
AU  - Griesser H
AD  - Department of Oncologic Pathology, Ontario Cancer Institute, Toronto, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Biomarkers
MH  - Humans
MH  - Lymphoma, T-Cell/diagnosis/*genetics/metabolism
MH  - Receptors, Antigen, T-Cell/*genetics
MH  - *Translocation, Genetic
RF  - 191
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/BF00191340 [doi]
PST - ppublish
SO  - Virchows Arch. 1995;426(4):323-38. doi: 10.1007/BF00191340.