PMID- 7599870
OWN - NLM
STAT- MEDLINE
DCOM- 19950810
LR  - 20071114
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 152
IP  - 1
DP  - 1995 Jul
TI  - Longitudinal evaluation of the association between pulmonary function and total 
      serum IgE.
PG  - 98-102
AB  - The role of immunoglobulin E (IgE) in the development and course of impaired 
      ventilatory function and chronic obstructive pulmonary disease (COPD) required 
      further study. This role has been examined in the longitudinal Tucson 
      Epidemiological Study of Airways Obstructive Disease, which started in 1972. The 
      association between IgE and longitudinal changes in pulmonary function measures 
      was examined in subjects in the community population sample in Tucson who had an 
      initial age of 35 or more. There were a total of 1,533 such subjects with lung 
      function tests over the 20 yr period who also had IgE determinations. A 
      significant inverse association was found between total serum IgE and FEV1/FVC 
      that was independent of smoking and asthma status. The finding was statistically 
      separate from the relation with age in all but elderly current smokers (age > 
      55). The magnitude of this effect in nonasthmatic subjects was relatively small. 
      For asthmatic subjects, however, the inverse association was larger in both 
      current and never smokers. Subjects excluded from the current analysis either did 
      not have an IgE measurement and/or had no pulmonary function values after 35 yr 
      of age. These findings suggest that higher IgE levels may indicate the presence 
      of a disease process that may involve inflammation and/or other mechanisms 
      related to IgE production, which impair lung function over time. However, in this 
      study we were not able to account for possible parental or inheritance 
      contributions to increases in total IgE, which have been shown to be important.
FAU - Sherrill, D L
AU  - Sherrill DL
AD  - Respiratory Sciences Center, University of Arizona College of Medicine, Tucson 
      85724, USA.
FAU - Lebowitz, M D
AU  - Lebowitz MD
FAU - Halonen, M
AU  - Halonen M
FAU - Barbee, R A
AU  - Barbee RA
FAU - Burrows, B
AU  - Burrows B
LA  - eng
GR  - HL14136/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Arizona/epidemiology
MH  - Asthma/*epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/physiology
MH  - Longitudinal Studies
MH  - Lung/physiopathology
MH  - Lung Diseases, Obstructive/*epidemiology/immunology
MH  - Male
MH  - Middle Aged
MH  - Smoking/epidemiology
MH  - Spirometry
MH  - Time Factors
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1164/ajrccm.152.1.7599870 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1995 Jul;152(1):98-102. doi: 
      10.1164/ajrccm.152.1.7599870.