PMID- 7601488
OWN - NLM
STAT- MEDLINE
DCOM- 19950808
LR  - 20131121
IS  - 0019-5189 (Print)
IS  - 0019-5189 (Linking)
VI  - 33
IP  - 3
DP  - 1995 Mar
TI  - Effect of neuropeptide FMRFamide on immobile behavior in rats.
PG  - 182-5
AB  - In the forced swimming induced immobility test, neuropeptide FMRFamide (5-20 
      micrograms) administered via the intracerebroventricular (icv) route, prolonged 
      immobilization period in rats. On the other hand, immunoneutralization of 
      endogenous FMRFamide by its antiserum (1 microliter, icv) significantly reduced 
      the duration of immobility. Intraperitoneal administration of amitriptyline (3 
      mg/kg), imipramine (5 mg/kg), fluoxetine (5 mg/kg) or amphetamine (0.5 mg/kg) 
      attenuated FMRFamide-induced prolongation of immobility. Biochemical studies 
      indicated that FMRFamide treatment had significant effects on rat brain 
      monoamines. FMRFamide significantly lowered the brain levels of 
      5-hydroxytryptamine and norepinephrine in the doses that prolonged the 
      immobility. These results that FMRFamide prolongs the duration of immobility, 
      perhaps by modulating the release of neurotransmitters like 5-hydroxytryptamine 
      and/or norepinephrine.
FAU - Muthal, A V
AU  - Muthal AV
AD  - Department of Pharmaceutical Sciences, Nagpur University Campus, India.
FAU - Chopde, C T
AU  - Chopde CT
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Exp Biol
JT  - Indian journal of experimental biology
JID - 0233411
RN  - 0 (Antidepressive Agents)
RN  - 0 (Neuropeptides)
RN  - 333DO1RDJY (Serotonin)
RN  - 64190-70-1 (FMRFamide)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antidepressive Agents/pharmacology
MH  - Brain/drug effects/metabolism
MH  - FMRFamide
MH  - *Immobilization
MH  - Injections, Intraventricular
MH  - Male
MH  - Molecular Sequence Data
MH  - Neuropeptides/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Norepinephrine/metabolism
MH  - Rats
MH  - Serotonin/metabolism
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
PST - ppublish
SO  - Indian J Exp Biol. 1995 Mar;33(3):182-5.