PMID- 7603090
OWN - NLM
STAT- MEDLINE
DCOM- 19950810
LR  - 20190830
IS  - 0047-6374 (Print)
IS  - 0047-6374 (Linking)
VI  - 78
IP  - 1
DP  - 1995 Jan 31
TI  - Time-dependent and tissue-specific variations of glutathione transferase activity 
      during gestation in the mouse.
PG  - 47-62
AB  - Glutathione transferases (GSTs; EC. 2.1.5.18) activity was measured in maternal 
      liver and conceptal tissues during gestation. In maternal liver, maximum activity 
      was found at gestational day (GD) 9 after which it slowly decreased up to the end 
      of gestation. The placental GSTs activity at GD18 was three times lower than that 
      found at GD14. Conversely, fetal liver GSTs at GD14 was about 75% that at GD18. 
      It was also observed that GSTs activity at GD9 and GD10 was higher in visceral 
      yolk sac than in embryo proper. Substrate specificity measurements, SDS PAGE 
      analysis and HPLC runs, carried out on GSH-affinity purified fractions, revealed 
      that with the progress of gestation in maternal liver an increase in pi class 
      GSTs subunit occurs, with a concomitant decrease in alpha class GSTs. With 
      respect to the time of gestation, a significant change in alpha, mu and pi class 
      GSTs expression also occurred in fetal liver and in chorioallantoic placenta. It 
      was concluded that during gestation the GSTs system is subjected to a 
      time-dependent and tissue-specific modulation which may play a protective role 
      against developmental toxicants.
FAU - Di Ilio, C
AU  - Di Ilio C
AD  - Istituto di Scienze Biochimiche, Universita di Chieti G. D'Annunzio, Italy.
FAU - Tiboni, G M
AU  - Tiboni GM
FAU - Sacchetta, P
AU  - Sacchetta P
FAU - Angelucci, S
AU  - Angelucci S
FAU - Bucciarelli, T
AU  - Bucciarelli T
FAU - Bellati, U
AU  - Bellati U
FAU - Aceto, A
AU  - Aceto A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Blotting, Western
MH  - Embryo, Mammalian/cytology/*enzymology
MH  - Female
MH  - Fetus/cytology/*enzymology
MH  - Gestational Age
MH  - Glutathione Transferase/*metabolism
MH  - Liver/cytology/*enzymology
MH  - Mice
MH  - Placenta/cytology/*enzymology
MH  - Pregnancy
MH  - Pregnancy, Animal/*metabolism
MH  - Random Allocation
EDAT- 1995/01/31 00:00
MHDA- 1995/01/31 00:01
CRDT- 1995/01/31 00:00
PHST- 1995/01/31 00:00 [pubmed]
PHST- 1995/01/31 00:01 [medline]
PHST- 1995/01/31 00:00 [entrez]
AID - 004763749401516O [pii]
AID - 10.1016/0047-6374(94)01516-o [doi]
PST - ppublish
SO  - Mech Ageing Dev. 1995 Jan 31;78(1):47-62. doi: 10.1016/0047-6374(94)01516-o.