PMID- 7603631
OWN - NLM
STAT- MEDLINE
DCOM- 19950810
LR  - 20131121
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 16
IP  - 1
DP  - 1995 Spring
TI  - Seizures and selective CA-1 hippocampal lesions induced by an excitotoxic cyanide 
      metabolite, 2-iminothiazolidine-4-carboxylic acid.
PG  - 115-22
AB  - Excitatory amino acid (EAA)-like and excitotoxic properties of the secondary 
      metabolite of cyanide, 2-iminothiazolidine-4-carboxylic acid, (2-ICA) were 
      evaluated because of its possible role in cyanide-induced neurotoxicity. 
      Intracerebroventricular (i.c.v.) injections of 2-ICA in mice produced 
      wild-running seizures that were qualitatively and quantitatively similar to 
      seizures observed with glutamate. 2-ICA, kainate and proline seizures were 
      prevented by both the NMDA and non-NMDA antagonists, MK-801 and CNQX, 
      respectively. In contrast, NMDA-induced seizures were prevented by MK-801, but 
      not CNQX. When infused i.c.v. in rats over a seven day period, 2-ICA produced 
      extensive and selective loss of CA-1 pyramidal neurons of the hippocampus. In 
      hippocampal slices preloaded with D-[3H]aspartate, 2-ICA superfusion did not 
      evoke release nor significantly augment potassium stimulated release of the 
      radiolabeled transmitter. These findings indicate 2-ICA has excitotoxic 
      properties and its role in cyanide neurotoxicity deserves further study.
FAU - Bitner, R S
AU  - Bitner RS
AD  - Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal 
      Sciences, Purdue University, West Lafayette, Indiana 47907-1334, USA.
FAU - Kanthasamy, A
AU  - Kanthasamy A
FAU - Isom, G E
AU  - Isom GE
FAU - Yim, G K
AU  - Yim GK
LA  - eng
GR  - BR0586/BR/FDA HHS/United States
GR  - ES04140/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Carboxylic Acids)
RN  - 0 (Cyanides)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - 9DLQ4CIU6V (Proline)
SB  - IM
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Animals
MH  - Carboxylic Acids/pharmacology
MH  - Cyanides/metabolism/*pharmacology
MH  - Dizocilpine Maleate/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Glutamic Acid/pharmacology
MH  - Hippocampus/*drug effects/physiology
MH  - Proline/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seizures/*chemically induced
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Neurotoxicology. 1995 Spring;16(1):115-22.