PMID- 7604939
OWN - NLM
STAT- MEDLINE
DCOM- 19950809
LR  - 20190821
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 50
IP  - 2
DP  - 1995 Feb
TI  - Immunoglobulin E levels in relationship to HIV-1 disease, route of infection, and 
      vitamin E status.
PG  - 157-61
AB  - Our recent studies have demonstrated that in early HIV-1 infection, elevation of 
      plasma immunoglobulin E (IgE) levels precedes the decline of CD4 cell count and 
      is influenced by vitamin E status. In order to further investigate the role of 
      IgE elevation in HIV-1 infection, we determined IgE levels in HIV-1-seropositive 
      and -seronegative intravenous drug users (IDUs) (n = 38), in relationship to 
      cellular and humoral immune function, liver enzymes, and vitamin E status. To 
      examine the possible impact of the route of HIV-1 infection on IgE levels, 
      comparisons between the cohorts of the HIV-1-seropositive and -seronegative IDUs 
      and homosexual men (n = 45) were also conducted. All HIV-1-seropositive 
      participants had significantly higher (P = 0.003) IgE levels than the 
      HIV-1-seronegative subjects. The HIV-1-seropositive IDUs, moreover, demonstrated 
      significantly higher (P = 0.01) IgE levels than HIV-1-seropositive homosexual 
      men, despite similar CD4 cell counts. Stepwise regression analysis was used to 
      evaluate the possible variables contributing to the IgE variation. HIV-1 status 
      (P = 0.0009), intravenous drug use (P = 0.014), CD8 cell counts (P = 0.0001), 
      plasma level of vitamin E (P = 0.006), and alcohol intake (P = 0.047) were 
      significant, accounting for 71% of the IgE elevation. These findings suggest that 
      IgE may serve as a sensitive marker to reflect the evolution of HIV-1 disease in 
      individuals from different risk groups.
FAU - Miguez-Burbano, M J
AU  - Miguez-Burbano MJ
AD  - Department of Epidemiology and Public Health, University of Miami School of 
      Medicine, FL 33101, USA.
FAU - Shor-Posner, G
AU  - Shor-Posner G
FAU - Fletcher, M A
AU  - Fletcher MA
FAU - Lu, Y
AU  - Lu Y
FAU - Moreno, J N
AU  - Moreno JN
FAU - Carcamo, C
AU  - Carcamo C
FAU - Page, B
AU  - Page B
FAU - Quesada, J
AU  - Quesada J
FAU - Sauberlich, H
AU  - Sauberlich H
FAU - Baum, M K
AU  - Baum MK
LA  - eng
GR  - 1-P50-MH42555/MH/NIMH NIH HHS/United States
GR  - D43-TW00017-5/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Serum Albumin)
RN  - 1406-18-4 (Vitamin E)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/blood/*immunology/transmission
MH  - CD4 Lymphocyte Count
MH  - Female
MH  - HIV Seronegativity/immunology
MH  - HIV Seropositivity/immunology
MH  - *HIV-1
MH  - Homosexuality, Male
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Male
MH  - Nutritional Status
MH  - Serum Albumin/analysis
MH  - Substance Abuse, Intravenous/complications/immunology
MH  - Vitamin E/*blood
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 10.1111/j.1398-9995.1995.tb05073.x [doi]
PST - ppublish
SO  - Allergy. 1995 Feb;50(2):157-61. doi: 10.1111/j.1398-9995.1995.tb05073.x.