PMID- 7605592
OWN - NLM
STAT- MEDLINE
DCOM- 19950816
LR  - 20191031
IS  - 0936-3076 (Print)
IS  - 0936-3076 (Linking)
VI  - 9
IP  - 1
DP  - 1995
TI  - Brain beta 2-microglobulin levels are elevated in the striatum in Parkinson's 
      disease.
PG  - 87-92
AB  - beta 2-Microglobulin (B2-MG) content was measured for the first time in the brain 
      (caudate nucleus, putamen, and cerebral cortex) from control and parkinsonian 
      patients by a highly sensitive sandwich enzyme immunoassay. The concentrations of 
      B2-MG in dopaminergic striatal regions were significantly higher in parkinsonian 
      patients than those in controls, whereas those in the cerebral cortex showed no 
      significant difference between parkinsonian and control subjects. Tumor necrosis 
      factor-alpha (TNF-alpha) concentrations were also increased in the striatum, 
      confirming our previous findings, but not in the cerebral cortex. Since TNF-alpha 
      may induce B2-MG expression, these results suggest that an immunological response 
      may occur in the nigrostriatal dopaminergic regions in Parkinson's disease.
FAU - Mogi, M
AU  - Mogi M
AD  - Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan.
FAU - Harada, M
AU  - Harada M
FAU - Kondo, T
AU  - Kondo T
FAU - Riederer, P
AU  - Riederer P
FAU - Nagatsu, T
AU  - Nagatsu T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - J Neural Transm Park Dis Dement Sect
JT  - Journal of neural transmission. Parkinson's disease and dementia section
JID - 8914371
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - Aged
MH  - Autopsy
MH  - Cerebral Cortex/chemistry
MH  - Corpus Striatum/*chemistry
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*diagnosis
MH  - Putamen/chemistry
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - beta 2-Microglobulin/*analysis
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/BF02252965 [doi]
PST - ppublish
SO  - J Neural Transm Park Dis Dement Sect. 1995;9(1):87-92. doi: 10.1007/BF02252965.