PMID- 7606924 OWN - NLM STAT- MEDLINE DCOM- 19950816 LR - 20180214 IS - 0301-0171 (Print) IS - 0301-0171 (Linking) VI - 71 IP - 1 DP - 1995 TI - Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death. PG - 41-3 AB - From a human fetal lung cDNA library we isolated and characterized a human cDNA highly homologous to Rp8, a rat gene associated with programmed cell death. This cDNA, termed PDCD2 (programmed cell death-2), contained an open reading frame of 1032 nucleotides encoding 344 amino acids; it revealed 81% identity in DNA sequence and 83% identity in amino acid sequence with rat Rp8. The gene represented by PDCD2 was expressed in all human tissues examined. We assigned the PDCD2 locus to chromosomal band 6q27 by fluorescence in situ hybridization (FISH). FAU - Kawakami, T AU - Kawakami T AD - Department of Biochemistry, Cancer Institute, Tokyo, Japan. FAU - Furukawa, Y AU - Furukawa Y FAU - Sudo, K AU - Sudo K FAU - Saito, H AU - Saito H FAU - Takami, S AU - Takami S FAU - Takahashi, E AU - Takahashi E FAU - Nakamura, Y AU - Nakamura Y LA - eng SI - GENBANK/S78085 PT - Journal Article PL - Switzerland TA - Cytogenet Cell Genet JT - Cytogenetics and cell genetics JID - 0367735 RN - 0 (Apoptosis Regulatory Proteins) RN - 0 (PDCD2 protein, human) RN - 0 (Proteins) RN - 9007-49-2 (DNA) SB - IM GS - PDCD2 GS - Rp8 MH - Amino Acid Sequence MH - Animals MH - Apoptosis/*genetics MH - Apoptosis Regulatory Proteins MH - Base Sequence MH - *Chromosomes, Human, Pair 6 MH - DNA MH - Humans MH - Molecular Sequence Data MH - Proteins/*genetics MH - Rats EDAT- 1995/01/01 00:00 MHDA- 1995/01/01 00:01 CRDT- 1995/01/01 00:00 PHST- 1995/01/01 00:00 [pubmed] PHST- 1995/01/01 00:01 [medline] PHST- 1995/01/01 00:00 [entrez] AID - 10.1159/000134058 [doi] PST - ppublish SO - Cytogenet Cell Genet. 1995;71(1):41-3. doi: 10.1159/000134058.