PMID- 7608264
OWN - NLM
STAT- MEDLINE
DCOM- 19950811
LR  - 20111117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 80
IP  - 7
DP  - 1995 Jul
TI  - Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and 
      HLA DQB1 are shared in endocrine autoimmune disease.
PG  - 2112-7
AB  - Because particular human leukocyte antigen (HLA) DQ alleles are the major 
      predisposing factors for type 1 diabetes mellitus (IDDM), we investigated whether 
      they are shared by other endocrine autoimmune diseases. We, therefore, analyzed 
      the HLA DQ genotypes of 171 patients with IDDM, 271 with Graves' disease (GD), 65 
      with Hashimoto's thyroiditis, 51 with postpartum thyroiditis, 53 with Addison's 
      disease (AD), and 271 healthy controls. HLA DQA1 and DQB1 alleles were defined by 
      polymerase chain reaction and sequence-specific oligonucleotide hybridization as 
      well as by single strand conformational polymorphism analysis. HLA DQA1*0501 was 
      significantly more frequent in IDDM (60%), GD (65%), and AD (70%) than in 
      controls (43%); DQA1*0301 was significantly more frequent only in IDDM (67% vs. 
      30% controls). The heterozygous state DQA1*0301/*0501 was found in 9% of controls 
      and 35% of IDDM (relative risk, 5.6). An arginine at position 52 on either DQA1 
      allele was significantly more frequent in patients with IDDM (94%), GD (80%), and 
      AD (89%) compared with controls (66%). HLA DQB1*0201 and DQB1*0302 were more 
      frequent in IDDM patients (*0201, 62% vs. 36% in controls, *0302, 59% vs. 19% 
      controls), whereas DQB1*0602 was less frequent in IDDM (4%) and GD (18% vs. 31% 
      of controls). In conclusion, endocrine autoimmunity has a common immunogenetic 
      background; susceptibility is conferred by DQA1*0501 as well as an arginine at 
      position 52 of DQA1 alleles, and protection against IDDM and GD is conferred by 
      DQB1*0602.
FAU - Badenhoop, K
AU  - Badenhoop K
AD  - Medical Clinic, Klinikum of the Johann Wolfgang Goethe-University, 
      Frankfurt/Main, Germany.
FAU - Walfish, P G
AU  - Walfish PG
FAU - Rau, H
AU  - Rau H
FAU - Fischer, S
AU  - Fischer S
FAU - Nicolay, A
AU  - Nicolay A
FAU - Bogner, U
AU  - Bogner U
FAU - Schleusener, H
AU  - Schleusener H
FAU - Usadel, K H
AU  - Usadel KH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (DNA Primers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Addison Disease/genetics/immunology
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - *Alleles
MH  - Autoimmune Diseases/*genetics/immunology
MH  - Base Sequence
MH  - DNA Primers
MH  - Diabetes Mellitus, Type 1/genetics/immunology
MH  - Disease Susceptibility/immunology
MH  - Female
MH  - *Genes, MHC Class II
MH  - Genetic Predisposition to Disease
MH  - Graves Disease/genetics/immunology
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Immunity, Innate/genetics/immunology
MH  - Molecular Sequence Data
MH  - Puerperal Disorders/genetics/immunology
MH  - Reference Values
MH  - Thyroiditis/genetics/immunology
MH  - Thyroiditis, Autoimmune/genetics/immunology
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1210/jcem.80.7.7608264 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1995 Jul;80(7):2112-7. doi: 10.1210/jcem.80.7.7608264.