PMID- 7613227
OWN - NLM
STAT- MEDLINE
DCOM- 19950822
LR  - 20161013
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 94
IP  - 1-2
DP  - 1995 Jan-Feb
TI  - Genotype of classic congenital adrenal hyperplasia and the 60-minute 
      adrenocorticotropic hormone stimulation test.
PG  - 10-3
AB  - Twelve Taiwanese patients with classic congenital adrenal hyperplasia and 86 
      family members underwent human leukocyte antigen (HLA) genotyping and the 
      60-minute adrenocorticotropic hormone (ACTH) stimulation test. The baseline serum 
      17-hydroxyprogesterone level (mean +/- SEM) before ACTH testing was 1.595 +/- 792 
      nmol/L in homozygotes, 4.6 +/- 0.5 nmol/L in heterozygotes, and 2.1 +/- 0.8 
      nmol/L in the unaffected group. The stimulated serum 17-hydroxyprogesterone level 
      (mean +/- SEM) was 1.926 +/- 778 nmol/L in homozygotes, 20.6 +/- 0.9 nmol/L in 
      heterozygotes, and 6.8 +/- 0.6 nmol/L in the unaffected group. There was minimal 
      overlap among the heterozygote and unaffected groups. The 60-minute ACTH 
      stimulation test can provide clinicians with hormonal criteria for the assessment 
      of the genotype of classic 21-hydroxylase deficiency in the Chinese population.
FAU - Tsai, W Y
AU  - Tsai WY
AD  - Department of Pediatrics, College of Medicine, National Taiwan University, 
      Taipei, R.O.C.
FAU - Lee, J S
AU  - Lee JS
FAU - Hsiao, P H
AU  - Hsiao PH
FAU - Hsieh, R P
AU  - Hsieh RP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
RN  - 0 (Hydroxyprogesterones)
RN  - 68-96-2 (17-alpha-Hydroxyprogesterone)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - 17-alpha-Hydroxyprogesterone
MH  - Adrenal Hyperplasia, Congenital/diagnosis/*genetics
MH  - *Adrenocorticotropic Hormone
MH  - Child
MH  - Female
MH  - Genotype
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Hydroxyprogesterones/blood
MH  - Male
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - J Formos Med Assoc. 1995 Jan-Feb;94(1-2):10-3.