PMID- 7613551
OWN - NLM
STAT- MEDLINE
DCOM- 19950818
LR  - 20161020
IS  - 1122-0643 (Print)
IS  - 1122-0643 (Linking)
VI  - 50
IP  - 2
DP  - 1995 Apr
TI  - Asthma and bronchial reactivity: a contribution from multivariate analysis.
PG  - 81-5
AB  - This study was performed on 508 young male candidates on the military pilot 
      course of the Air Force Academy. Observations of the following parameters were 
      made: immunoglobulin E (IgE) level, skin sensitivity test (prick test) to most 
      common continuous and seasonal allergens, and results of nonspecific bronchial 
      provocation tests with methacholine. The analysis strategy that has been 
      developed consists of two techniques, "multiple correspondence analysis (MCA)" 
      and "automatic classification". The correlation between the categories of the 
      characters evaluated are: degree of high skin reactivity in relation to high IgE 
      levels, hyperreactivity to low methacholine dose (noticed mainly in subjects 
      allergic to continuous antigens), low degree of skin reactivity (both to 
      continuous and seasonal antigens and found in relation to a low methacholine 
      dose) and medium and low IgE levels. The cluster analysis defined three different 
      classes of subjects: 1) 51.97% of the total observed subjects. 68.82% of those 
      subjects that showed IgE levels above 7300 and a high reactivity to low 
      methacholine dose; 2) 15.94% of subjects with a severe allergy to pollens; and 3) 
      32.09% of subjects with IgE levels lower than 900, low bronchial reactivity and 
      no allergic component for either seasonal or continuous antigens. The use of 
      multivariate statistical techniques in this field of pathophysiology has allowed 
      a confirmative-explorative study of allergic phenomena in relation to several 
      characters, and the determination of classes of subjects characterized by 
      well-defined categories.
FAU - Brancato, I
AU  - Brancato I
AD  - Institute of Tuberculosis and Respiratory Diseases, 2nd University of Naples, 
      Italy.
FAU - Signoriello, G
AU  - Signoriello G
FAU - de Angelis, C P
AU  - de Angelis CP
FAU - Verde, R
AU  - Verde R
FAU - Cioffi, D
AU  - Cioffi D
FAU - Maselli, R
AU  - Maselli R
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Monaldi Arch Chest Dis
JT  - Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
JID - 9307314
RN  - 0 (Allergens)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens
MH  - Asthma/*immunology/physiopathology
MH  - Bronchial Hyperreactivity/*immunology/physiopathology
MH  - Bronchial Provocation Tests
MH  - Cluster Analysis
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Italy
MH  - Male
MH  - Methacholine Chloride
MH  - Military Personnel
MH  - Multivariate Analysis
MH  - Pollen
MH  - Rhinitis, Allergic, Perennial/immunology/physiopathology
MH  - Rhinitis, Allergic, Seasonal/immunology/physiopathology
MH  - Skin Tests
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
PST - ppublish
SO  - Monaldi Arch Chest Dis. 1995 Apr;50(2):81-5.