PMID- 7615044
OWN - NLM
STAT- MEDLINE
DCOM- 19950824
LR  - 20190909
IS  - 0902-4441 (Print)
IS  - 0902-4441 (Linking)
VI  - 55
IP  - 1
DP  - 1995 Jul
TI  - Assessment of minimal residual disease in acute promyelocytic leukaemia with 
      t(15;17) by chromosome painting.
PG  - 10-3
AB  - To detect the minimal residual disease (MRD) in acute promyelocytic leukaemia 
      patients treated with all-trans retinoic acid, we compared the sensitivity of 
      metaphase fluorescence in situ hybridization (FISH) with conventional analysis of 
      G-banded metaphases. 5 out of 6 patients studied at diagnosis showed the t(15;17) 
      translocation. 4 out of 5 patients carrying t(15;17) achieved complete remission 
      and conventional cytogenetic conversion. In 3 cases the whole chromosome painting 
      (WCP) probe 17 discovered one normal chromosome 17 and two fragments indicative 
      of t(15;17) persistence. The FISH-WCP technique seems to be highly sensitive and 
      recommendable in monitoring leukaemias with specific chromosome rearrangements.
FAU - Temperani, P
AU  - Temperani P
AD  - Department of Medical Sciences, University of Modena, Italy.
FAU - Vaccari, P
AU  - Vaccari P
FAU - Giacobbi, F
AU  - Giacobbi F
FAU - Gandini, G
AU  - Gandini G
FAU - Ferrari, M G
AU  - Ferrari MG
FAU - Emilia, G
AU  - Emilia G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization
MH  - Leukemia, Promyelocytic, Acute/*diagnosis/drug therapy/genetics
MH  - Male
MH  - Middle Aged
MH  - Neoplasm, Residual
MH  - Translocation, Genetic
MH  - Tretinoin/therapeutic use
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1111/j.1600-0609.1995.tb00226.x [doi]
PST - ppublish
SO  - Eur J Haematol. 1995 Jul;55(1):10-3. doi: 10.1111/j.1600-0609.1995.tb00226.x.