PMID- 7616376
OWN - NLM
STAT- MEDLINE
DCOM- 19950823
LR  - 20190711
IS  - 0022-3549 (Print)
IS  - 0022-3549 (Linking)
VI  - 84
IP  - 3
DP  - 1995 Mar
TI  - Fate of water-soluble polymers administered via different routes.
PG  - 349-54
AB  - The biological fate of synthetic water-soluble polymers administered to mice by 
      injection at different sites is described. After intraperitoneal (ip), 
      subcutaneous (sc), and intramuscular (im) injections of 125I-labeled poly(vinyl 
      alcohol) (PVA) and poly(ethylene glycol) (PEG) with various molecular weights, 
      the time-course of polymer concentration in the blood was measured and analyzed 
      pharmacokinetically. The location of PVA in the body was similar to that of PEG; 
      that is, the elimination from the injection sites and the translocation from the 
      injection sites into the blood circulation were similar for both polymers. The 
      elimination rate of both polymers from the injection sites increased in the order 
      ip > sc > im. After sc and im injections of polymers, the elimination rate 
      decreased with an increase in the molecular weight, whereas the elimination rate 
      of polymers injected showed no molecular weight dependence over the range 
      studied, regardless of the type of polymers used. The time-course of polymer 
      concentration in the blood depended largely on the injection route of the 
      polymers, and the polymer elimination from the blood circulation was enhanced 
      with the decreasing molecular weight of polymers injected. It was concluded that 
      the molecular weight and the injection site are the important factors that affect 
      the concentration profile of polymers in the blood circulation.
FAU - Yamaoka, T
AU  - Yamaoka T
AD  - Research Center for Biomedical Engineering, Kyoto University, Japan.
FAU - Tabata, Y
AU  - Tabata Y
FAU - Ikada, Y
AU  - Ikada Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Alcohols)
RN  - 0 (Glycols)
RN  - 0 (Polymers)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Alcohols
MH  - Animals
MH  - Drug Administration Routes
MH  - Female
MH  - Glycols
MH  - Mathematics
MH  - Mice
MH  - Molecular Weight
MH  - Polymers/metabolism/*pharmacokinetics
MH  - Time Factors
MH  - Water
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
AID - S0022-3549(15)49743-6 [pii]
AID - 10.1002/jps.2600840316 [doi]
PST - ppublish
SO  - J Pharm Sci. 1995 Mar;84(3):349-54. doi: 10.1002/jps.2600840316.