PMID- 7623007
OWN - NLM
STAT- MEDLINE
DCOM- 19950829
LR  - 20190830
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 46
IP  - 1
DP  - 1995 May
TI  - Detection of human herpesvirus 6 DNAs in samples from several body sites of 
      patients with exanthem subitum and their mothers by polymerase chain reaction 
      assay.
PG  - 52-5
AB  - Polymerase chain reaction amplification was used to detect human herpesvirus 6 
      (HHV-6) DNAs in peripheral blood mononuclear cells (MNCs), plasma, saliva, stool, 
      and urine from three patients with exanthem subitum and in peripheral blood MNCs, 
      plasma, and saliva from their mothers. HHV-6 DNAs were detected in MNCs during 
      and after the disease and were found in plasma only in the acute phase. The virus 
      DNAs were also detected in saliva after recovery from the illness and were found 
      persistently or intermittently in stool but not in urine samples after the onset 
      of the disease. In contrast, one of the three mothers excreted HHV-6 DNAs 
      persistently in saliva. None of the mothers had the virus DNAs in peripheral 
      blood MNCs and plasma nor a significant increase in antibody titers to HHV-6 
      after possible exposure from their children. These findings suggest systemic 
      replication of HHV-6 during the acute phase in patients with exanthem subitum and 
      persistent infection of the virus in several organs after recovery from the 
      disease.
FAU - Suga, S
AU  - Suga S
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Aichi, 
      Japan.
FAU - Yazaki, T
AU  - Yazaki T
FAU - Kajita, Y
AU  - Kajita Y
FAU - Ozaki, T
AU  - Ozaki T
FAU - Asano, Y
AU  - Asano Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - DNA, Viral/analysis
MH  - Exanthema Subitum/blood/urine/*virology
MH  - Feces
MH  - Female
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Infant
MH  - Leukocytes, Mononuclear/virology
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Saliva/virology
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1002/jmv.1890460112 [doi]
PST - ppublish
SO  - J Med Virol. 1995 May;46(1):52-5. doi: 10.1002/jmv.1890460112.