PMID- 7624800
OWN - NLM
STAT- MEDLINE
DCOM- 19950831
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 269
IP  - 5224
DP  - 1995 Aug 4
TI  - A gene outside the human MHC related to classical HLA class I genes.
PG  - 693-5
AB  - By presenting antigenic peptides to T lymphocytes, major histocompatibility 
      complex (MHC) class I molecules play important roles in the human immune system. 
      Knowledge is limited on the evolutionary history of human MHC class I-related 
      molecules. An expressed class I gene, MR1, has now been identified on human 
      chromosome 1q25, outside the MHC. In contrast to other known human divergent 
      class I genes, MR1 encodes peptide-binding domains similar to those encoded by 
      human leukocyte antigen (HLA) class I genes on chromosome 6 and by nonmammalian 
      classical MHC class I genes. This gene may thus contribute to understanding the 
      evolution of the MHC.
FAU - Hashimoto, K
AU  - Hashimoto K
AD  - Institute for Comprehensive Medical Science, Fujita Health University, Aichi, 
      Japan.
FAU - Hirai, M
AU  - Hirai M
FAU - Kurosawa, Y
AU  - Kurosawa Y
LA  - eng
SI  - GENBANK/U22963
SI  - GENBANK/U24235
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MR1 protein, human)
RN  - 0 (Minor Histocompatibility Antigens)
SB  - IM
GS  - MR1
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Biological Evolution
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 6
MH  - *Genes, MHC Class I
MH  - Histocompatibility Antigens Class I/chemistry/*genetics
MH  - Humans
MH  - *Major Histocompatibility Complex
MH  - Minor Histocompatibility Antigens
MH  - Molecular Sequence Data
EDAT- 1995/08/04 00:00
MHDA- 1995/08/04 00:01
CRDT- 1995/08/04 00:00
PHST- 1995/08/04 00:00 [pubmed]
PHST- 1995/08/04 00:01 [medline]
PHST- 1995/08/04 00:00 [entrez]
AID - 10.1126/science.7624800 [doi]
PST - ppublish
SO  - Science. 1995 Aug 4;269(5224):693-5. doi: 10.1126/science.7624800.