PMID- 7626092
OWN - NLM
STAT- MEDLINE
DCOM- 19950825
LR  - 20141120
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 212
IP  - 3
DP  - 1995 Jul 26
TI  - Cytochrome c oxidase catalysis of the reduction of nitric oxide to nitrous oxide.
PG  - 1054-60
AB  - Reduction of nitric oxide (NO) to nitrous oxide (N2O) is catalyzed by bovine 
      heart cytochrome c oxidase (CcO) in anaerobic solutions at pH 7.2 and 20 degrees 
      C. Cyanide inhibits and forms Fea3(3+)CN. The mononitrosyl (Fea3(2+)NO), but not 
      the dinitrosyl (Fea3(2+)NO; CuB+NO), is a likely intermediate in N2O formation. 
      One-electron reduction of NO at Fea3(2+) could yield N2O via HNO. However, a 
      two-electron reduction of the NO ligand to give an intermediate that reacts with 
      a second NO to give N2O and H2O appears more likely. Conversion of NO to N2O is 
      favored by low levels of both NO and O2, higher NO levels can inhibit both 
      cytochrome c oxidase and NO reductase activities. Raising the O2 level will favor 
      catalysis of NO oxidation to NO2 by CcO. The reactions of NO and the specific CcO 
      activity that occur in tissue will be critically dependent on NO, O2, and CcO 
      levels.
FAU - Zhao, X J
AU  - Zhao XJ
AD  - Department of Biochemistry and Molecular Biology, Colorado State University, Fort 
      Collins 80523, USA.
FAU - Sampath, V
AU  - Sampath V
FAU - Caughey, W S
AU  - Caughey WS
LA  - eng
GR  - GM30306/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - K50XQU1029 (Nitrous Oxide)
SB  - IM
MH  - Animals
MH  - Catalysis
MH  - Cattle
MH  - Electrochemistry
MH  - Electron Transport
MH  - Electron Transport Complex IV/*metabolism
MH  - Hydrogen-Ion Concentration
MH  - In Vitro Techniques
MH  - Models, Chemical
MH  - Myocardium/enzymology
MH  - Nitric Oxide/*metabolism
MH  - Nitrous Oxide/*metabolism
MH  - Oxidation-Reduction
MH  - Spectrophotometry, Infrared
EDAT- 1995/07/26 00:00
MHDA- 1995/07/26 00:01
CRDT- 1995/07/26 00:00
PHST- 1995/07/26 00:00 [pubmed]
PHST- 1995/07/26 00:01 [medline]
PHST- 1995/07/26 00:00 [entrez]
AID - S0006-291X(85)72076-1 [pii]
AID - 10.1006/bbrc.1995.2076 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1995 Jul 26;212(3):1054-60. doi: 
      10.1006/bbrc.1995.2076.