PMID- 7627930
OWN - NLM
STAT- MEDLINE
DCOM- 19950905
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 82
IP  - 1
DP  - 1995 Jul 1
TI  - Chromosome X numerical abnormalities in patients with non-Hodgkin's lymphoma. A 
      study of 59 patients using fluorescence in situ hybridization.
PG  - 23-9
AB  - Chromosome X numerical abnormalities are frequently observed in non-Hodgkin's 
      lymphoma (NHL), with an incidence of 3% to 14% for chromosomal loss and 7% to 33% 
      for chromosomal gain. Because sex chromosome numerical abnormalities are thought 
      to be due to aging, little information is known about their relation to gender, 
      therapy, and prognosis. Therefore, to determine the incidence and clinical 
      relevance of this abnormality in NHL, we studied specimens from 59 NHL patients 
      (31 men and 28 women) by fluorescence in situ hybridization (FISH) using a 
      directly conjugated centromeric probe for chromosome X. The median age for the 
      entire group was 52 years (range, 31-88 years). All specimens were obtained by 
      fine-needle aspiration of diseased lymph nodes. Sex-matched lymphocytes from 
      benign hyperplastic lymph nodes were used as controls. The overall incidence of 
      chromosome X numerical abnormalities was 49.2%. Female patients had a higher 
      overall incidence than males (76% vs. 24%; p < 0.001). The median percentage of 
      cells involved in this abnormality in each specimen was 5.2%. There was no 
      statistically significant difference in the incidence in previously treated than 
      untreated patients (53.1% vs. 44.4%; p < 0.75) and in intermediate-grade NHL than 
      low-grade NHL (61.1% vs. 50%; p < 0.75). There was a trend towards a higher 
      incidence of chromosome X loss in older patients. While the difference in the 
      incidence of chromosome X abnormalities observed between women and men may be due 
      to the difference in the normal copy numbers of this chromosome in each sex 
      group, this abnormality remained higher than any other autosomal chromosome 
      abnormality in NHL previously evaluated by FISH. We conclude that, although FISH 
      detected a high incidence of chromosome X numerical abnormalities and that 
      females had a higher incidence than males, only a small percentage of the cells 
      were involved, suggesting that this abnormality is most likely a secondary 
      genetic defect that is not important in the pathogenesis of NHL.
FAU - Younes, A
AU  - Younes A
AD  - Division of Medicine, University of Texas M.D. Anderson Cancer Center, Houston 
      77030, USA.
FAU - Jendiroba, D
AU  - Jendiroba D
FAU - Katz, R
AU  - Katz R
FAU - Hill, D
AU  - Hill D
FAU - Cabanillas, F
AU  - Cabanillas F
FAU - Andreeff, M
AU  - Andreeff M
LA  - eng
GR  - CA-16672/CA/NCI NIH HHS/United States
GR  - CA-55164/CA/NCI NIH HHS/United States
GR  - CA-57639/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aneuploidy
MH  - Chromosome Aberrations/*pathology
MH  - Chromosome Disorders
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Non-Hodgkin/*pathology
MH  - Male
MH  - Middle Aged
MH  - X Chromosome/*ultrastructure
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 0165-4608(94)00289-N [pii]
AID - 10.1016/0165-4608(94)00289-n [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1995 Jul 1;82(1):23-9. doi: 10.1016/0165-4608(94)00289-n.