PMID- 7628876
OWN - NLM
STAT- MEDLINE
DCOM- 19950907
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 62
IP  - 3
DP  - 1995 Jul 28
TI  - Manifestations of cancer cachexia induced by colon 26 adenocarcinoma are not 
      fully ascribable to interleukin-6.
PG  - 332-6
AB  - In order to further clarify the role of interleukin 6 (IL-6) in the pathogenesis 
      of cachexia, recombinant human IL-6 (hIL-6) was administered s.c. by osmotic pump 
      for 9 days at a dose of 1 or 10 micrograms/day into CDF1 mice inoculated with a 
      non-cachexia-inducing subclone of colon 26 adenocarcinoma (clone 5), or with a 
      cachexia-inducing subclone (clone 20) of this malignancy. The serum level of IL-6 
      in non-cachectic mice with clone-5 tumors was 35% lower than in cachectic mice 
      bearing clone 20 of colon 26 adenocarcinoma on the 19th day after tumor 
      inoculation. IL-6 administration induced anemia, thrombocytosis and visceral 
      organ hypertrophy not only in mice with clone-5 tumors but also in control mice 
      with no tumor burden. Lipolysis and proteolysis became conspicuous when a large 
      dose (10 micrograms/day) of IL-6 was infused into mice with clone-5 tumors. 
      However, IL-6 supplementation did not induce loss of body weight, a decline in 
      food intake or lymphocytopenia, which were characteristically observed in 
      cachectic mice with clone-20 tumors. In conclusion, IL-6 appears to be a 
      permissive factor for the development of cachexia but, while it can induce some 
      of the symptoms typical of cachexia, it cannot in itself induce the full 
      cachectic syndrome.
FAU - Soda, K
AU  - Soda K
AD  - Department of Integrated Medicine and Surgery, Omiya Medical Center, Jichi 
      Medical School, Saitama, Japan.
FAU - Kawakami, M
AU  - Kawakami M
FAU - Kashii, A
AU  - Kashii A
FAU - Miyata, M
AU  - Miyata M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adenocarcinoma/blood/*complications
MH  - Animals
MH  - Body Weight/drug effects
MH  - Cachexia/chemically induced/*etiology
MH  - Cell Division/drug effects
MH  - Colonic Neoplasms/blood/*complications
MH  - Eating/drug effects
MH  - Interleukin-6/blood/*toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred DBA
MH  - Neoplasm Transplantation
EDAT- 1995/07/28 00:00
MHDA- 1995/07/28 00:01
CRDT- 1995/07/28 00:00
PHST- 1995/07/28 00:00 [pubmed]
PHST- 1995/07/28 00:01 [medline]
PHST- 1995/07/28 00:00 [entrez]
AID - 10.1002/ijc.2910620317 [doi]
PST - ppublish
SO  - Int J Cancer. 1995 Jul 28;62(3):332-6. doi: 10.1002/ijc.2910620317.