PMID- 7629658
OWN - NLM
STAT- MEDLINE
DCOM- 19950901
LR  - 20181130
IS  - 0265-2048 (Print)
IS  - 0265-2048 (Linking)
VI  - 12
IP  - 2
DP  - 1995 Mar-Apr
TI  - Properties of multiphase microspheres of poly(D,L-lactic-co-glycolic acid) 
      prepared by a potentiometric dispersion technique.
PG  - 155-63
AB  - Multiphase microspheres of poly(D,L-lactic-co-glycolic acid) (PLGA) were prepared 
      by a multiple emulsion potentiometric dispersion technique. Water-soluble 
      compounds were dissolved in the aqueous phase (W) and emulsified in soybean oil 
      (O) to form a stable emulsion. This primary emulsion was dispersed in a solution 
      of PLGA and acetonitrile (O) to form a W/O/O emulsion. The W/O/O emulsion was 
      then dispersed in a hardening solution of light mineral oil (O) using a 
      potentiometric dispersion technique to produce microspheres of the W/O/O/O type 
      with a very narrow and selective size distribution. The size of the microspheres 
      was controlled by varying the internal diameter of the conductive infusion tube 
      or by the variation of voltage applied to the conductive tube. Particle size 
      analysis revealed a particle size distribution of 1-50 microns for microspheres 
      made by this method as compared to a distribution of 50-500 microns for 
      microspheres made by conventional agitation methods. Chlorpheniramine maleate was 
      encapsulated with a loading efficiency of 88.9% with the potentiometric method as 
      compared with a loading efficiency of 74.3% for the agitation method.
FAU - O'Donnell, P B
AU  - O'Donnell PB
AD  - College of Pharmacy, University of Texas at Austin 78712-1074, USA.
FAU - Iwata, M
AU  - Iwata M
FAU - McGinity, J W
AU  - McGinity JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Microencapsul
JT  - Journal of microencapsulation
JID - 8500513
RN  - 0 (Polymers)
RN  - 0 (Surface-Active Agents)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Chemistry, Pharmaceutical
MH  - Electrochemistry
MH  - *Lactic Acid
MH  - Microscopy, Electron, Scanning
MH  - Microspheres
MH  - Particle Size
MH  - *Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - *Potentiometry/methods
MH  - Surface-Active Agents/chemistry
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
AID - 10.3109/02652049509015286 [doi]
PST - ppublish
SO  - J Microencapsul. 1995 Mar-Apr;12(2):155-63. doi: 10.3109/02652049509015286.