PMID- 7630398
OWN - NLM
STAT- MEDLINE
DCOM- 19950906
LR  - 20091119
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 376
IP  - 6538
DP  - 1995 Jul 27
TI  - Induction of epidermis and inhibition of neural fate by Bmp-4.
PG  - 331-3
AB  - During gastrulation in vertebrates, ectodermal cells choose between two fates, 
      neural and epidermal. The nervous system forms in response to signals from the 
      Spemann organizer; ectoderm that does not receive these signals becomes 
      epidermis. Unexpectedly, however, in Xenopus, neural tissue also forms when 
      cell-cell communication within the ectoderm is disrupted by cell dissociation or 
      by antagonists of the growth factor activin. These observations suggest that 
      epidermal specification depends on local signalling, by activin or a close 
      relative, and that neural tissue forms when this communication is blocked. Here 
      we report that bone morphogenesis protein 4 (Bmp-4), a relative of activin that 
      is expressed in the embryo at the time of ectodermal fate determination, is a 
      potent epidermal inducer and neural inhibitor, the first reported in any 
      vertebrate. Activin can inhibit neuralization by inducing mesoderm, but does not 
      induce epidermis. Moreover, the dominant-negative activin receptor, which 
      stimulates neuralization when expressed in the embryo, blocks Bmp-4 in our assay. 
      Our findings demonstrate that epidermal fate can be induced, and thus provide 
      further evidence that neural specification is under inhibitory control in 
      vertebrates.
FAU - Wilson, P A
AU  - Wilson PA
AD  - Rockefeller University, New York, New York 10021-6322, USA.
FAU - Hemmati-Brivanlou, A
AU  - Hemmati-Brivanlou A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Follistatin)
RN  - 0 (Glycoproteins)
RN  - 0 (Growth Substances)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Growth Factor)
RN  - 104625-48-1 (Activins)
RN  - 57285-09-3 (Inhibins)
RN  - EC 2.7.11.30 (Activin Receptors)
SB  - IM
MH  - Activin Receptors
MH  - Activins
MH  - Animals
MH  - Base Sequence
MH  - Bone Morphogenetic Proteins
MH  - Culture Techniques
MH  - Ectoderm/physiology
MH  - *Embryonic Induction
MH  - Epidermis/*embryology
MH  - Follistatin
MH  - Gastrula/physiology
MH  - Glycoproteins/physiology
MH  - Growth Substances/*physiology
MH  - Humans
MH  - Inhibins/physiology
MH  - Molecular Sequence Data
MH  - Neurons/*physiology
MH  - Oligodeoxyribonucleotides
MH  - Proteins/*physiology
MH  - Receptors, Growth Factor/physiology
MH  - Xenopus
EDAT- 1995/07/27 00:00
MHDA- 1995/07/27 00:01
CRDT- 1995/07/27 00:00
PHST- 1995/07/27 00:00 [pubmed]
PHST- 1995/07/27 00:01 [medline]
PHST- 1995/07/27 00:00 [entrez]
AID - 10.1038/376331a0 [doi]
PST - ppublish
SO  - Nature. 1995 Jul 27;376(6538):331-3. doi: 10.1038/376331a0.