PMID- 7632740 OWN - NLM STAT- MEDLINE DCOM- 19950911 LR - 20190610 IS - 0006-3002 (Print) IS - 0006-3002 (Linking) VI - 1263 IP - 1 DP - 1995 Jul 25 TI - Structure of the int-5, a novel MMTV integration genomic locus containing mouse early transposon LTR homology region. PG - 89-92 AB - Previous studies have reported the cloning and identification of the int-5, a novel mouse mammary tumor virus (MMTV) integration locus involved in mammary tumorigenesis. Here we report the characterization of the 5.5 kb region from this novel MMTV integration site. Our results show that the region after the MMTV integration site, a 258 bp sequence is homologous (100%) to the mouse early transposon (mETn) long-terminal repeat and other sequences of the this transposon are not present in the 5.5 kb region. Our results also show for the first time the tumor specific expression of mETn and expression of the region downstream of the MMTV integration site that is homologous to mETn-LTR in D2 mammary tumors. FAU - Durgam, V R AU - Durgam VR AD - Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio 78284-7836, USA. FAU - Easton, J A AU - Easton JA FAU - Surya, R AU - Surya R FAU - Tekmal, R R AU - Tekmal RR LA - eng SI - GENBANK/U19724 GR - CA57559/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - Netherlands TA - Biochim Biophys Acta JT - Biochimica et biophysica acta JID - 0217513 RN - 0 (DNA Transposable Elements) SB - IM GS - int-5 MH - Animals MH - Base Sequence MH - DNA Transposable Elements/*genetics MH - Gene Expression MH - Mammary Glands, Animal/metabolism MH - Mammary Neoplasms, Experimental/metabolism MH - Mammary Tumor Virus, Mouse/*genetics MH - Mice MH - Mice, Inbred BALB C MH - Molecular Sequence Data MH - Repetitive Sequences, Nucleic Acid/*genetics EDAT- 1995/07/25 00:00 MHDA- 1995/07/25 00:01 CRDT- 1995/07/25 00:00 PHST- 1995/07/25 00:00 [pubmed] PHST- 1995/07/25 00:01 [medline] PHST- 1995/07/25 00:00 [entrez] AID - 0167-4781(95)00093-V [pii] AID - 10.1016/0167-4781(95)00093-v [doi] PST - ppublish SO - Biochim Biophys Acta. 1995 Jul 25;1263(1):89-92. doi: 10.1016/0167-4781(95)00093-v.