PMID- 7633014
OWN - NLM
STAT- MEDLINE
DCOM- 19950912
LR  - 20170214
IS  - 1060-0280 (Print)
IS  - 1060-0280 (Linking)
VI  - 29
IP  - 4
DP  - 1995 Apr
TI  - Cyclosporine and vancomycin disposition during continuous venovenous 
      hemodiafiltration.
PG  - 374-7
AB  - OBJECTIVE: To report cyclosporine and vancomycin disposition during continuous 
      venovenous hemodiafiltration (CVVHD) in a 41-year-old heart transplant patient 
      while in the intensive care unit at a primary and tertiary care teaching 
      hospital. CASE SUMMARY: The patient received a 60-mg infusion of cyclosporine 
      over 24 hours and vancomycin 1 g over 1 hour. Blood samples subsequently were 
      collected and analyzed using whole blood monoclonal radioimmunoassay and 
      fluorescence polarization immunoassay, respectively. Blood samples were measured 
      every hour from the arterial and venous lines of the apparatus, as were 
      ultrafiltrate drug concentrations. Drug clearance rates into the ultrafiltrate 
      subsequently were calculated. DISCUSSION: Measurements of ultrafiltrate detected 
      no cyclosporine. A slight variation existed between arterial and venous drug 
      concentrations, which was not statistically significant (p > 0.05, paired 
      Student's t-test). Analysis of vancomycin samples revealed a steady decline of 
      drug concentration, with 4.75% of the dose eliminated in the ultrafiltrate. 
      Vancomycin arterial and venous concentrations decreased from 24.4 and 23.3 mg/L 
      to 15.7 and 12.3 mg/L, respectively. CONCLUSIONS: Vancomycin is eliminated by 
      CVVHD and it may be necessary for these patients to receive the drug more 
      frequently. In contrast, cyclosporine is not removed effectively by CVVHD; 
      therefore, replacement doses are not warranted.
FAU - Munar, M Y
AU  - Munar MY
AD  - College of Pharmacy, Oregon State University, Oregon Health Sciences University, 
      USA.
FAU - Doyle, I C
AU  - Doyle IC
FAU - Meyer, M M
AU  - Meyer MM
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Ann Pharmacother
JT  - The Annals of pharmacotherapy
JID - 9203131
RN  - 6Q205EH1VU (Vancomycin)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
CIN - Ann Pharmacother. 1995 Sep;29(9):941. PMID: 8547754
MH  - Adult
MH  - Cyclosporine/administration & dosage/*blood
MH  - *Heart Transplantation
MH  - *Hemodiafiltration/classification
MH  - Hospitals, Teaching
MH  - Humans
MH  - Infusions, Intravenous
MH  - Intensive Care Units
MH  - Male
MH  - Oregon
MH  - Vancomycin/administration & dosage/*blood
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1177/106002809502900406 [doi]
PST - ppublish
SO  - Ann Pharmacother. 1995 Apr;29(4):374-7. doi: 10.1177/106002809502900406.