PMID- 7633202
OWN - NLM
STAT- MEDLINE
DCOM- 19950908
LR  - 20161013
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 93
IP  - 11-12
DP  - 1994 Nov-Dec
TI  - Cytogenetic investigations in trisomy 21 with reciprocal 4/9 translocation: 
      report of a case.
PG  - 958-60
AB  - A 3-month-old male infant with Down's syndrome resulting from de novo trisomy 21 
      had an additional reciprocal translocation between the long arms of chromosomes 4 
      and 9: 47,XY,+21,rcp t(4;9)(q35;q22.3). Both C- and Ag-NOR bandings showed that 
      the extra chromosome 21 was maternal in origin, but that the translocated 
      chromosome 9 was from the father. To evaluate the nature of the translocation, 
      fluorescence in situ hybridization (FISH) with whole chromosome painting probes 
      (Coatasomes 4 & 9), followed by an enzymatic precipitation (HRP-DAB) assay was 
      used. Whole chromosome FISH demonstrated the origin of the translocated region 
      and clarified the karyotype. Enzymatic methods achieved the same result and were 
      kept as a permanent record.
FAU - Hou, J W
AU  - Hou JW
AD  - Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
FAU - Wang, T R
AU  - Wang TR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
SB  - IM
MH  - *Chromosomes, Human, Pair 4
MH  - *Chromosomes, Human, Pair 9
MH  - Down Syndrome/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - *Translocation, Genetic
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
PST - ppublish
SO  - J Formos Med Assoc. 1994 Nov-Dec;93(11-12):958-60.